Prediction of Anti‐Alzheimer's Activity of Flavonoids Targeting Acetylcholinesterase in silico

S Das, MA Laskar, SD Sarker… - Phytochemical …, 2017 - Wiley Online Library
Introduction Prenylated and pyrano‐flavonoids of the genus Artocarpus JR Forster & G.
Forster are well known for their acetylcholinesterase (AChE) inhibitory, anti‐cholinergic, anti …

[图书][B] Dementia in clinical practice: a neurological perspective: pragmatic studies in the cognitive function clinic

AJ Larner - 2014 - Springer
What contribution (s) to the diagnosis and care of people with cognitive disorders can a
neurology-led dementia clinic make? Naïve readers of recent United Kingdom policy …

Poor safety and tolerability hamper reaching a potentially therapeutic dose in the use of thalidomide for Alzheimer's disease: results from a double-blind, placebo …

B Decourt, D Drumm-Gurnee, J Wilson… - Current Alzheimer …, 2017 - ingentaconnect.com
Introduction: To date there is no cure for Alzheimer's disease (AD). After amyloid beta
immunotherapies have failed to meet primary endpoints of slowing cognitive decline in AD …

[HTML][HTML] In vitro evaluation of the neuroprotective potential of Olea dioica against Aβ peptide-induced toxicity in human neuroblastoma SH-SY5Y cells

PG Kenchappa, Y Karthik, PD Vijendra… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a type of neurodegenerative disease, associated with the
hastening of ROS, acetylcholinesterase (AChE) activity, and amyloid β peptides plaques in …

Cholinesterase as a target for drug development in Alzheimer's disease

P Sharma, MK Tripathi, SK Shrivastava - Targeting Enzymes for …, 2020 - Springer
Alzheimer's disease (AD) is an enormous healthcare challenge, and 50 million people are
currently suffering from it. There are several pathophysiological mechanisms involved, but …

[HTML][HTML] In Vitro Antioxidant, Anti-Diabetes, Anti-Dementia, and Inflammation Inhibitory Effect of Trametes pubescens Fruiting Body Extracts

KH Im, TK Nguyen, J Choi, TS Lee - Molecules, 2016 - mdpi.com
Trametes pubescens, white rot fungus, has been used for folk medicine in Asian countries to
treat ailments such as cancer and gastrointestinal diseases. This study was initiated to …

[HTML][HTML] Advances in designs for Alzheimer's disease clinical trials

J Cummings, H Gould, K Zhong - American journal of …, 2012 - ncbi.nlm.nih.gov
There is an urgent need to identify new treatments for the rapidly growing population of
people with Alzheimer's disease (AD). Innovations in clinical trial designs many help to …

Computer aided drug design studies in the discovery of secondary metabolites targeted against age-related neurodegenerative diseases

L Scotti, M Tullius Scotti - Current topics in medicinal chemistry, 2015 - ingentaconnect.com
Secondary metabolites are plant products that occur usually in differentiated cells, generally
not being necessary for the cells themselves, but likely useful for the plant as a whole …

HPLC–DAD characterization of phenolic profile and in vitro antioxidant, anticholinesterase, and antidiabetic activities of five mushroom species from Turkey

F Çayan, G Tel-Çayan, E Deveci, ME Duru - 3 Biotech, 2021 - Springer
In this study, Daedalea quercina (L.) Pers., Hydnum repandum L., Inonotus radiatus
(Sowerby) P. Karst., Omphalotus olearius (DC.) Singer, and Schizophyllum commune Fr …

Derivatization, molecular docking and in vitro acetylcholinesterase inhibitory activity of glycyrrhizin as a selective anti-Alzheimer agent

FM Abdel Bar, DM Elimam, AS Mira… - Natural product …, 2019 - Taylor & Francis
Abstract Acetylcholinesterase inhibitors (AChE-Is) increase both level and duration of action
of acetylcholine (ACh); thus, alleviate symptoms of Alzheimer's disease (AD). Glycyrrhizin, is …