Glycogen synthase kinase 3 (GSK-3) inhibitors have aroused a great interest for medicinal
chemists and pharmaceutical companies in the last years. In fact, some candidates have …

The study was conducted to explore the anticholinesterase inhibition property of eugenol
derived molecules. Ten eugenol derivatives were synthesized and evaluated for the …

Abstract Background The efficacy of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside
(TSG) treatment on cognitive decline in individuals with Alzheimer's disease (AD) has not …

Objective To evaluate the current status of trial registration on the Chinese Clinical Trial
Registry (ChiCTR). Design In this descriptive study, a multi-dimensional grouping analysis …

In the current work, we developed a computational pipeline method for predicting the
binding affinities of studied compounds at the specific target sites. Since many approved …

As mimetic compounds of the natural alkaloid mackinazolinone, forty pyrido [1, 2-a] thiazolo
[5, 4-d] pyrimidinone were designed and synthesized from a bioisosterism approach. The …

Reversible acetylcholinesterase inhibitors are an important group of drug compounds that
are used medicinally to treat Alzheimer's disease. In this study, dissociation constant values …

Background Whether in the context of monitoring disease progression or in assessing the
effects of interventions, a major challenge in dementia research is determining when an …

Alzheimer's disease is a brain disease that slowly destroys memory and thinking skills, and
eventually, the ability to carry out the simplest tasks. It begins slowly and gets worse over …