Critically ill patients have increased variability in beta-lactam antibiotic (beta-lactam)
exposure due to alterations in their volume of distribution and elimination. Therapeutic drug …

(1) Background: To develop evidence-based algorithms for targeted antibiotic therapy of
infection-related ventilator-associated complications (IVACs) caused by non-fermenting …

The objective of this study was to assess the relationship between joint pharmacokinetic/
pharmacodynamic (PK/PD) target attainment of continuous infusion (CI) ceftazidime …

Background Optimal β-lactam dosing for the treatment of Gram-negative bacteria
bloodstream infections (GNB-BSIs) remains a debated issue. Herein, the efficacy and safety …

Critically ill patients are characterized by substantial pathophysiological changes that alter
the pharmacokinetics (PK) of hydrophilic antibiotics, including carbapenems. Meropenem is …

Purpose: Antimicrobial stewardship programs are important for reducing antimicrobial
resistance because they can readjust antibiotic prescriptions to local guidelines, switch …

Assessment of glomerular filtration rate (GFR) is necessary for dose adjustments of beta-
lactam that are excreted by the kidneys, such as meropenem. The aim of this study was to …

Background Carbapenems and β-lactam and β‐lactamase inhibitors (BLBLIs) have been
used empirically in nosocomial pneumonia, but their efficacy and safety are controversial …

Ceftobiprole is a fifth-generation cephalosporin used for different Gram-positive bacterial
infections. A population pharmacokinetic analysis was conducted in real-life clinical patients …

Introduction The importance of antibiotic treatment for sepsis in critically ill septic patients is
well established. Consistently achieving the dose of antibiotics required to optimally kill …