A complete blood cell count (CBC) is one of the most common laboratory tests in medicine.
For example, at our institution alone, approximately 1800 CBCs are ordered every day, and …

Myeloproliferative disorders (MPDs) constitute a group of hematopoietic malignancies that
feature enhanced proliferation and survival of one or more myeloid lineage cells. William …

Fluorescence in situ hybridization (FISH) provides an important adjunct to conventional
cytogenetics and molecular studies in the evaluation of chromosome abnormalities …

Human myeloid leukemias provide models of maturation arrest and differentiation therapy of
cancer. The genetic lesions of leukemia result in a block of differentiation (maturation arrest) …

The role of UVA-radiation—the major fraction in sunlight—in human skin carcinogenesis is
still elusive. We here report that different UVA exposure regime (4× 5 J/cm 2 per week or 1× …

RT-PCR is the method of choice for detecting BCR–ABL in CML and ALL. The three
predominant mRNA transcripts found are e1a2 (in ALL), e13a2, and e14a2 (in CML and …

Purpose. Chronic myeloid leukemia (CML), a hematopoietic stem cell cancer representing
15–20% of adult leukemias, is discussed. Epidemiology, staging biology, and monitoring …

Cancers arise from stem cells in adult tissues and the cells that make up a cancer reflect the
same stem cell→ progeny→ differentiation progression observed in normal tissues. All adult …

A Leucemia Mielóide Crônica (LMC), cuja incidência é de um a dois casos para cada 100
mil habitantes por ano, corresponde de 15% a 20% das leucemias. É uma doença …

Context.—The diagnosis and classification of leukemia is becoming increasingly complex.
Current classification schemes incorporate morphologic features, immunophenotype …