Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …

The epithelial lining of the airway forms the first barrier against environmental insults, such
as inhaled cigarette smoke, which is the primary risk factor for the development of chronic …

Cystic Fibrosis (CF) is a genetic disorder that arises due to mutations in the Cystic Fibrosis
Transmembrane Conductance Regulator gene, which encodes for a protein responsible for …

Chronic obstructive pulmonary disease (COPD) patients frequently suffer from multiple
comorbidities, resulting in poor outcomes for these patients. Diabetes is observed at a …

Over the past years, the Xenopus embryo has emerged as an incredibly useful model
organism for studying the formation and function of cilia and ciliated epithelia in vivo. This …

Tobacco smoking has been established to contribute to the pathogenesis of various
respiratory diseases including chronic obstructive pulmonary disease (COPD), lung cancer …

Airway remodeling is associated with dysregulation of epithelial-mesenchymal transition
(EMT) in patients with asthma. Sinomenine (Sin) is an effective, biologically active alkaloid …

Background Airway epithelium integrity is essential to maintain its role of mechanical and
functional barrier. Recurrent epithelial injuries require a complex mechanism of repair to …

There is now convincing evidence that the airway epithelium drives the pathogenesis of
COPD. A major aspect of this is the disease-related reduction in barrier function that is …

Extensive remodeling of the airways is a major characteristic of chronic inflammatory lung
diseases such as asthma or chronic obstructive pulmonary disease (COPD). To elucidate …