Resistencia bacteriana a los antibióticos: una crisis global
JI Alós - Enfermedades infecciosas y microbiología clínica, 2015 - Elsevier
La introducción de los antibióticos en la práctica clínica supuso una de las intervenciones
más importantes para el control de las enfermedades infecciosas. Los antibióticos han …
más importantes para el control de las enfermedades infecciosas. Los antibióticos han …
Metagenomics for neurological infections—expanding our imagination
PS Ramachandran, MR Wilson - Nature Reviews Neurology, 2020 - nature.com
Over the past two decades, the diagnosis rate for patients with encephalitis has remained
poor despite advances in pathogen-specific testing such as PCR and antigen assays …
poor despite advances in pathogen-specific testing such as PCR and antigen assays …
Antimicrobial resistance
HD Marston, DM Dixon, JM Knisely, TN Palmore… - Jama, 2016 - jamanetwork.com
Importance The development of antibiotics is considered among the most important
advances of modern science. Antibiotics have saved millions of lives. However …
advances of modern science. Antibiotics have saved millions of lives. However …
Diagnostic test accuracy of a 2-transcript host RNA signature for discriminating bacterial vs viral infection in febrile children
JA Herberg, M Kaforou, VJ Wright, H Shailes… - Jama, 2016 - jamanetwork.com
Importance Because clinical features do not reliably distinguish bacterial from viral infection,
many children worldwide receive unnecessary antibiotic treatment, while bacterial infection …
many children worldwide receive unnecessary antibiotic treatment, while bacterial infection …
A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus
disease-19 (COVID-19), has emerged as the cause of a global pandemic. We used RNA …
disease-19 (COVID-19), has emerged as the cause of a global pandemic. We used RNA …
Host gene expression classifiers diagnose acute respiratory illness etiology
Acute respiratory infections caused by bacterial or viral pathogens are among the most
common reasons for seeking medical care. Despite improvements in pathogen-based …
common reasons for seeking medical care. Despite improvements in pathogen-based …
Robust classification of bacterial and viral infections via integrated host gene expression diagnostics
TE Sweeney, HR Wong, P Khatri - Science translational medicine, 2016 - science.org
Improved diagnostics for acute infections could decrease morbidity and mortality by
increasing early antibiotics for patients with bacterial infections and reducing unnecessary …
increasing early antibiotics for patients with bacterial infections and reducing unnecessary …
Association of RNA biosignatures with bacterial infections in febrile infants aged 60 days or younger
Importance Young febrile infants are at substantial risk of serious bacterial infections;
however, the current culture-based diagnosis has limitations. Analysis of host expression …
however, the current culture-based diagnosis has limitations. Analysis of host expression …
A novel host-proteome signature for distinguishing between acute bacterial and viral infections
Bacterial and viral infections are often clinically indistinguishable, leading to inappropriate
patient management and antibiotic misuse. Bacterial-induced host proteins such as …
patient management and antibiotic misuse. Bacterial-induced host proteins such as …
Dysregulated transcriptional responses to SARS-CoV-2 in the periphery
SARS-CoV-2 infection has been shown to trigger a wide spectrum of immune responses
and clinical manifestations in human hosts. Here, we sought to elucidate novel aspects of …
and clinical manifestations in human hosts. Here, we sought to elucidate novel aspects of …