Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

Executive summary Every infant, child, and adolescent will experience pain at times
throughout their life. Childhood pain ranges from acute to chronic, and includes procedural …

Science is among humanity's greatest achievements, yet scientific censorship is rarely
studied empirically. We explore the social, psychological, and institutional causes and …

Objective To investigate the dynamic functional connectivity of thalamocortical networks in
interictal migraine patients and whether clinical features are associated with abnormal …

Objective To evaluate the efficacy, tolerability, and safety of eptinezumab 100 and 300 mg
compared with placebo in patients with the dual diagnosis of chronic migraine (CM) and …

Migraine headache results from activation of meningeal nociceptors, however, the
hypothalamus is activated many hours before the emergence of pain. How hypothalamic …

Background Chronic migraine is a common and highly disabling disorder. Functional MRI
has indicated that abnormal brain region activation is linked with chronic migraine. Drugs …

Migraine is the most common neurological disorder in the world, affecting 12% of the
population. Migraine involves the central nervous system, trigeminal nerves and meninges …

Migraine is an evolving, and sometimes lifelong disorder. The prevalence of episodic
migraine peaks among individuals aged in their late 30s, implying a tendency for the …

Background Clinical trials and observational studies with anti-calcitonin gene-related
peptide antibodies poorly investigated their impact on migraine prodromal and …