Synthetic toxic chemicals (toxicants) and biological poisons (toxins) have been developed
as chemical warfare agents in the last century. At the time of their initial consideration as …

Sulfur and nitrogen mustards, bis (2-chloroethyl) sulfide and tertiary bis (2-chloroethyl)
amines, respectively, are vesicant warfare agents with alkylating activity. Moreover …

Monocytes and their descendants, macrophages, play a key role in the defence against
pathogens. They also contribute to the pathogenesis of inflammatory diseases. Therefore, a …

Since their use during the First World War, Blister agents have posed a major threat to the
individuals and have caused around two million casualties. Major incidents occurred not …

Two platinum (IV) complexes were designed and prepared by conjugation of cisplatin and
oxaliplatin units with a DNA-damaging agent, chlorambucil, respectively. By taking a joint …

Sulfur mustard (SM) and its derivatives are potent genotoxic agents, which have been
shown to trigger the activation of poly (ADP-ribose) polymerases (PARPs) and the depletion …

The objective of this study is to present and critically analyze the current state of knowledge
on the chromatographic analysis of chemical warfare agents (CWAs) and their metabolites …

Transient receptor potential family channels (TRPs) have been identified as relevant targets
in many pharmacological as well as toxicological studies. TRP channels are ubiquitously …

Nitrogen mustards, a family of DNA alkylating agents, marked the start of cancer
pharmacotherapy. While traditionally characterized by their dose-limiting toxic effects …

Despite its worldwide ban, the warfare agent sulfur mustard (SM) still represents a realistic
threat, due to potential release in terroristic attacks and asymmetric conflicts. Therefore, the …