Associating cellular epigenetic models with human phenotypes
T Lappalainen, JM Greally - Nature Reviews Genetics, 2017 - nature.com
Epigenetic association studies have been carried out to test the hypothesis that
environmental perturbations trigger cellular reprogramming, with downstream effects on …
environmental perturbations trigger cellular reprogramming, with downstream effects on …
Current achievements and applications of transcriptomics in personalized cancer medicine
S Supplitt, P Karpinski, M Sasiadek… - International Journal of …, 2021 - mdpi.com
Over the last decades, transcriptome profiling emerged as one of the most powerful
approaches in oncology, providing prognostic and predictive utility for cancer management …
approaches in oncology, providing prognostic and predictive utility for cancer management …
AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors
Abstract The Animal Transcription Factor DataBase (AnimalTFDB) is a resource aimed to
provide the most comprehensive and accurate information for animal transcription factors …
provide the most comprehensive and accurate information for animal transcription factors …
Transcription factors and DNA play hide and seek
DM Suter - Trends in cell biology, 2020 - cell.com
Transcription factors (TFs) bind to specific DNA motifs to regulate the expression of target
genes. To reach their binding sites, TFs diffuse in 3D and perform local motions such as 1D …
genes. To reach their binding sites, TFs diffuse in 3D and perform local motions such as 1D …
The architecture of binding cooperativity between densely bound transcription factors
The binding of transcription factors (TFs) along genomes is restricted to a subset of sites
containing their preferred motifs. TF-binding specificity is often attributed to the co-binding of …
containing their preferred motifs. TF-binding specificity is often attributed to the co-binding of …
Toward a mechanistic understanding of DNA binding by forkhead transcription factors and its perturbation by pathogenic mutations
S Dai, L Qu, J Li, Y Chen - Nucleic acids research, 2021 - academic.oup.com
Forkhead box (FOX) proteins are an evolutionarily conserved family of transcription factors
that play numerous regulatory roles in eukaryotes during developmental and adult life …
that play numerous regulatory roles in eukaryotes during developmental and adult life …
Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders
SB Estruch, SA Graham, M Quevedo… - Human molecular …, 2018 - academic.oup.com
FOXP transcription factors play important roles in neurodevelopment, but little is known
about how their transcriptional activity is regulated. FOXP proteins cooperatively regulate …
about how their transcriptional activity is regulated. FOXP proteins cooperatively regulate …
Egg-shell derived carbon dots for base pair selective DNA binding and recognition
The development of base pair selective fluorescent binding probes and their interaction
mode with nucleic acids have created great interest for sensing and biomedical applications …
mode with nucleic acids have created great interest for sensing and biomedical applications …
TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle …
Both environmental factors and genetic loci have been associated with coronary artery
disease (CAD), however gene-gene and gene-environment interactions that might identify …
disease (CAD), however gene-gene and gene-environment interactions that might identify …
Engineering altered protein–DNA recognition specificity
Protein engineering is used to generate novel protein folds and assemblages, to impart new
properties and functions onto existing proteins, and to enhance our understanding of …
properties and functions onto existing proteins, and to enhance our understanding of …