The renin–angiotensin system is an important component of the cardiovascular system.
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …

Ion channels are multimeric, transmembrane proteins that selectively mediate ion flux across
the plasma membrane in a variety of cells including vascular smooth muscle cells (VSMCs) …

Cardiovascular disorders are among the leading causes of death worldwide, especially
hypertension, a silent killer syndrome requiring multiple drug therapy for appropriate …

Combinatorial therapy is a promising strategy for combating complex disorders due to
improved efficacy and reduced side effects. However, screening new drug combinations …

Despite significant advances in health care over the last 50 years, the global cardiovascular
disease burden continues to increase with dire im‐plications. It is well known that …

Context Hypertension affects one third of the US adult population. Although cost-
effectiveness analyses of antihypertensive medicines have been published, a …

The associations among cognitive function, hypertension, and dyslipidemia in older adults
are controversial. Therefore, we investigated the associations among cognitive decline …

Objective: We conducted a large-scale meta-analysis and subgroup analysis to compare the
effect of fixed-dose combination (FDC) therapy with that of free-equivalent combination …

We present a dendrimer-based hybrid formulation strategy to explore the potential of poly
(amidoamine) PAMAM dendrimers to be used as drug carriers for combination therapy of an …

Backgrounds. High prevalence of multidrug use combined with age-related alteration of
pharmacokinetic and pharmacodynamics makes elderly hypertensive patients vulnerable to …