[HTML][HTML] Advantages and limitations of animal schizophrenia models

M Białoń, A Wąsik - International Journal of Molecular Sciences, 2022 - mdpi.com
Mental illness modeling is still a major challenge for scientists. Animal models of
schizophrenia are essential to gain a better understanding of the disease etiopathology and …

Parvalbumin interneuron vulnerability and brain disorders

JB Ruden, LL Dugan, C Konradi - Neuropsychopharmacology, 2021 - nature.com
Parvalbumin-expressing interneurons (PV-INs) are highly vulnerable to stressors and have
been implicated in many neuro-psychiatric diseases such as schizophrenia, Alzheimer's …

A hypothalamic novelty signal modulates hippocampal memory

S Chen, L He, AJY Huang, R Boehringer, V Robert… - Nature, 2020 - nature.com
The ability to recognize information that is incongruous with previous experience is critical
for survival. Novelty signals have therefore evolved in the mammalian brain to enhance …

[HTML][HTML] Hippocampal oxytocin receptors are necessary for discrimination of social stimuli

T Raam, KM McAvoy, A Besnard, AH Veenema… - Nature …, 2017 - nature.com
Oxytocin receptor (Oxtr) signaling in neural circuits mediating discrimination of social stimuli
and affiliation or avoidance behavior is thought to guide social recognition. Remarkably, the …

[HTML][HTML] The role of parvalbumin interneurons in neurotransmitter balance and neurological disease

L Nahar, BM Delacroix, HW Nam - Frontiers in psychiatry, 2021 - frontiersin.org
While great progress has been made in the understanding of neurological illnesses, the
pathologies, and etiologies that give rise to these diseases still remain an enigma, thus, also …

Rediscovering area CA2: unique properties and functions

SM Dudek, GM Alexander, S Farris - Nature Reviews Neuroscience, 2016 - nature.com
Hippocampal area CA2 has several features that distinguish it from CA1 and CA3, including
a unique gene expression profile, failure to display long-term potentiation and relative …

The social hippocampus

A Montagrin, C Saiote, D Schiller - Hippocampus, 2018 - Wiley Online Library
The concept of cognitive map has been proposed as a way to organize our experiences and
guide behavior across all domains of cognition. The hippocampus has been identified as the …

[HTML][HTML] Role of hippocampal CA2 region in triggering sharp-wave ripples

A Oliva, A Fernández-Ruiz, G Buzsáki, A Berényi - Neuron, 2016 - cell.com
Sharp-wave ripples (SPW-Rs) in the hippocampus are implied in memory consolidation, as
shown by observational and interventional experiments. However, the mechanism of their …

[HTML][HTML] A direct lateral entorhinal cortex to hippocampal CA2 circuit conveys social information required for social memory

J Lopez-Rojas, CA de Solis, F Leroy, ER Kandel… - Neuron, 2022 - cell.com
The hippocampus is essential for different forms of declarative memory, including social
memory, the ability to recognize and remember a conspecific. Although recent studies …

Neural circuits regulating prosocial behaviors

JJ Walsh, DJ Christoffel, RC Malenka - Neuropsychopharmacology, 2023 - nature.com
Positive, prosocial interactions are essential for survival, development, and well-being.
These intricate and complex behaviors are mediated by an amalgamation of neural circuit …