Histamine has long been known to trigger allergic reactions and gastric acid secretion.
However, it was later discovered that, in the brain, histamine regulates basic homeostatic …

The purpose of this review is to present animal research models that can be used to screen
and/or repurpose medications for the treatment of alcohol abuse and dependence. The …

The purpose of this review paper is to present evidence that rat animal models of alcoholism
provide an ideal platform for developing and screening medications that target alcohol …

Histamine, which is synthesized by histidine decarboxylase (HDC), does not only modulate
the immune system, but is also acting as a neurotransmitter. Histaminergic neurons project …

The purpose of this review is to present up-to-date pharmacological, genetic, and behavioral
findings from the alcohol-preferring P rat and summarize similar past work. Behaviorally, the …

Histamine H 3 receptors are best known as presynaptic receptors inhibiting the release of
histamine, as well as other neurotransmitters including acetylcholine and dopamine …

Military personnel deployed in combat operations are highly prone to develop Parkinson's
disease (PD) in later lives. PD largely involves dopaminergic pathways with hallmarks of …

Introduction: The histamine H3 receptor (H3R) plays a pivotal role in a plethora of
therapeutic areas. Blocking the H3R with antagonists/inverse agonists has been postulated …

This study investigates if the day of the week a person is admitted with a hip fracture
influences the quality of care they receive. We found those admitted Thursday and Friday …

The role of Histamine H3 receptors (H3Rs) in memory, and the prospective of H3R
antagonists in pharmacological control of neurodegenerative disorders, eg, Alzheimer …