Osteoarthritis (OA) is a highly prevalent condition, and the hand is the most commonly
affected site. Patients with hand OA frequently report symptoms of pain, functional limitations …

Accumulating evidence suggests that inflammation has a key role in the pathogenesis of
osteoarthritis (OA). Nitric oxide (NO) has been established as one of the major inflammatory …

Osteoarthritis (OA) is a painful and disabling disease that affects millions of people
worldwide. Symptom-alleviating treatments exist, although none with long-term efficacy …

Osteoarthritis (OA) is one of the most common musculoskeletal degenerative diseases and
contributes to heavy socioeconomic burden. Current pharmacological and conventional non …

Background pain is the leading symptom of osteoarthritis (OA) and is often chronic in nature,
leading to significant morbidity and decreased quality of life. Duloxetine, a selective …

Osteoarthritis (OA) therapy remains a large challenge since no causative treatment options
are so far available. Despite some main pathways contributing to OA are identified its …

Osteoarthritis (OA) is an incapacitating and one of the most common physically degenerative
conditions with an assorted etiology and a highly complicated molecular mechanism that to …

Diacerein (DCN), a BCS II compound, suffers from poor aqueous solubility and limited
bioavailability. Solid dispersion systems (SD) of DCN were prepared by solvent evaporation …

Objectives Osteoarthritis (OA) is the most common form of arthritis characterised by cartilage
degradation, synovitis and pain. Disease modifying treatments for OA are not available. The …

Diacerein (DCN), a potent anti-inflammatory API used to treat osteoarthritis yet, it suffers from
poor water solubility which affects its oral absorption. Unabsorbed colonic DCN is converted …