CD4+ T cell help in cancer immunology and immunotherapy

J Borst, T Ahrends, N Bąbała, CJM Melief… - Nature Reviews …, 2018 - nature.com
Cancer immunotherapy aims to promote the activity of cytotoxic T lymphocytes (CTLs) within
a tumour, assist the priming of tumour-specific CTLs in lymphoid organs and establish …

Natural killer cells: development, maturation, and clinical utilization

AM Abel, C Yang, MS Thakar… - Frontiers in …, 2018 - frontiersin.org
Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-
tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells …

The role of natural killer cells in autoimmune diseases

UC Kucuksezer, E Aktas Cetin, F Esen… - Frontiers in …, 2021 - frontiersin.org
Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells

N Huot, C Planchais, P Rosenbaum, V Contreras… - Nature …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA generally becomes
undetectable in upper airways after a few days or weeks postinfection. Here we used a …

Immune dysfunction and autoimmunity as pathological mechanisms in autism spectrum disorders

HK Hughes, E Mills Ko, D Rose… - Frontiers in cellular …, 2018 - frontiersin.org
Autism spectrum disorders (ASD) are a group of heterogeneous neurological disorders that
are highly variable and are clinically characterized by deficits in social interactions …

Intercellular communication within the virus microenvironment affects the susceptibility of cells to secondary viral infections

B Song, X Sheng, JL Justice, KK Lum, PJ Metzger… - Science …, 2023 - science.org
Communication between infected cells and cells in the surrounding tissue is a determinant
of viral spread. However, it remains unclear how cells in close or distant proximity to an …

NK cells in host responses to viral infections

VC Lam, LL Lanier - Current opinion in immunology, 2017 - Elsevier
Highlights•NK cells generate long-lived antigen-specific memory cells.•NK cells regulate
viral load and cytokine production of innate immune cells.•NK cells indirectly modulate …

Exhausted NK cells and cytokine storms in COVID-19: Whether NK cell therapy could be a therapeutic choice

M Ghasemzadeh, A Ghasemzadeh, E Hosseini - Human immunology, 2022 - Elsevier
The global outbreak of coronavirus-2019 (COVID-19) still claims more lives daily around the
world due to the lack of a definitive treatment and the rapid tendency of virus to mutate …

Virus–host interactions in foot-and-mouth disease virus infection

K Li, C Wang, F Yang, W Cao, Z Zhu… - Frontiers in …, 2021 - frontiersin.org
Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals,
which has been regarded as a persistent challenge for the livestock industry in many …

NK cells limit therapeutic vaccine–induced CD8+T cell immunity in a PD-L1–dependent manner

MO Diniz, A Schurich, SK Chinnakannan… - Science Translational …, 2022 - science.org
A better understanding of mechanisms that regulate CD8+ T cell responses to therapeutic
vaccines is needed to develop approaches to enhance vaccine efficacy for chronic viral …