Early in the HIV epidemic, lipodystrophy, characterized by subcutaneous fat loss
(lipoatrophy), with or without central fat accumulation (lipohypertrophy), was recognized as a …

Abstract Purpose of Review The proportion of overweight and obese persons with HIV
(PWH) has increased since the introduction of antiretroviral therapy (ART). We aim to …

Context Adipose tissue is increasingly recognized as an active endocrine organ with many
secretory products and part of the innate immune system. With obesity, macrophages …

Two of the crucial aspects of human immunodeficiency virus (HIV) infection are (i) viral
persistence in reservoirs (precluding viral eradication) and (ii) chronic inflammation (directly …

Although white AT can contribute to anti-infectious immune responses, it can also be
targeted and perturbed by pathogens. The AT's immune involvement is primarily due to …

In mammals, adipose tissue, composed of BAT and WAT, collaborates in energy partitioning
and performs metabolic regulatory functions. It is the most flexible tissue in the body …

Combination antiretroviral therapy (cART) against HIV infection dramatically reduces AIDS-
related morbidity. However, many patients under cART display HIV-associated …

The success of highly active antiretroviral therapy (HAART) has determined a dramatic
decline in AIDS-and immunodeficiency-related causes of death in the HIV-infected …

Aims/hypothesis Circulating lipopolysaccharide-binding protein (LBP) is an acute-phase
reactant known to be increased in obesity. We hypothesised that LBP is produced by …

Introduction: Lipodystrophy is a term used to describe a metabolic complication of fat loss, fat
gain, or a combination of fat loss and gain, which is associated with some antiretroviral …