Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease

B Jia, Y Zou, X Han, JW Bae, CO Jeon - Trends in Microbiology, 2023 - cell.com
Cardiovascular disease (CVD) is a health problem worldwide, and elevated cholesterol
levels are a key risk factor for the disease. Dysbiotic gut microbiota has been shown to be …

[HTML][HTML] Foam cells in atherosclerosis: novel insights into its origins, consequences, and molecular mechanisms

Y Gui, H Zheng, RY Cao - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Foam cells play a vital role in the initiation and development of atherosclerosis. This review
aims to summarize the novel insights into the origins, consequences, and molecular …

Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis

Y Zhou, H Zhou, L Hua, C Hou, Q Jia, J Chen… - Free Radical Biology …, 2021 - Elsevier
Ferroptosis and pyroptosis have not been fully studied in atherosclerosis. We aimed to
investigate the expression of ferroptosis-related and pyroptosis-related proteins in human …

[HTML][HTML] Triacylglycerol uptake and handling by macrophages: From fatty acids to lipoproteins

L Deng, S Kersten, R Stienstra - Progress in Lipid Research, 2023 - Elsevier
Macrophages are essential innate immune cells and form our first line of immune defense.
Also known as professional phagocytes, macrophages interact and take up various …

[HTML][HTML] Protective effects of oleic acid and polyphenols in extra virgin olive oil on cardiovascular diseases

Y Lu, J Zhao, Q Xin, R Yuan, Y Miao, M Yang… - Food Science and …, 2024 - Elsevier
The Mediterranean diet has long been recognized as one of the most effective ways to
prevent and improve cardiovascular disease. Extra virgin olive oil (EVOO) is the typical …

Endothelial function and endothelial progenitor cells in systemic lupus erythematosus

A Mak, JKY Chan - Nature Reviews Rheumatology, 2022 - nature.com
The observations that traditional cardiovascular disease (CVD) risk factors fail to fully
account for the excessive cardiovascular mortality in patients with systemic lupus …

RNA modifications in cardiovascular diseases, the potential therapeutic targets

Y Wu, S Zhan, Y Xu, X Gao - Life Sciences, 2021 - Elsevier
More than one hundred RNA modifications decorate the chemical and topological properties
of these ribose nucleotides, thereby executing their biological functions through post …

[HTML][HTML] Asprosin inhibits macrophage lipid accumulation and reduces atherosclerotic burden by up-regulating ABCA1 and ABCG1 expression via the p38/Elk-1 …

J Zou, C Xu, ZW Zhao, SH Yin, G Wang - Journal of Translational …, 2022 - Springer
Background Asprosin, a newly discovered adipokine, is a C-terminal cleavage product of
profibrillin. Asprosin has been reported to participate in lipid metabolism and cardiovascular …

Trimethylamine N-oxide promotes oxidative stress and lipid accumulation in macrophage foam cells via the Nrf2/ABCA1 pathway

ZS Luo, XC Yu, C Wang, HY Zhao, X Wang… - Journal of physiology …, 2024 - Springer
Recently, trimethylamine N-oxide (TMAO) has been considered a risk factor for
cardiovascular disease and has a proatherogenic effect. Many studies have found that …

NLRP3 inflammasome in atherosclerosis: putting out the fire of inflammation

BZ Shao, HY Xu, YC Zhao, XR Zheng, F Wang… - Inflammation, 2023 - Springer
Atherosclerosis (AS) is a chronic inflammatory disease with thickening or hardening of the
arteries, which led to the built-up of plaques in the inner lining of an artery. Among all the …