Chronic kidney disease (CKD) represents a global health concern, and its prevalence is
increasing. The ultimate therapeutic option for CKD is kidney transplantation. However, the …

The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in
the field of transplantation, with excellent short-term outcome. However, the chronic …

Sensitive and specific biomarkers are needed to detect early kidney injury. The objective of
the present work was to develop a sensitive quantitative urinary test to identify renal injury in …

The renin-angiotensin-aldosterone system regulates renal vasomotor activity, maintains
optimal salt and water homeostasis, and controls tissue growth in the kidney. However …

Objectives: This study sought to assess whether spironolactone treatment reduces the high
incidence of cardiovascular and cerebrovascular (CCV) morbidity and mortality in …

Experimental evidence suggests that aldosterone contributes to progressive kidney disease.
Angiotensin-converting enzyme inhibitors and angiotensin type 1 receptor antagonists …

After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical
problem. Cyclosporine-induced renal injury has been described in solid organs recipients …

Diabetic nephropathy (DN) is the leading cause of end stage renal disease (ESRD).
Although the pathogenesis of DN is multifactorial, local inflammatory stress may result from …

Mineralocorticoid receptor (MR) antagonists, for example, spironolactone and eplerenone,
are in clinical use to treat hypertension. Increasing evidence suggests that mineralocorticoid …

Aldosterone induces myocardial fibrosis and vascular inflammation via proinflammatory and
profibrotic cytokines. The effect of spironolactone on renal inflammation and renal function …