[HTML][HTML] FDA-approved oximes and their significance in medicinal chemistry

J Dhuguru, E Zviagin, R Skouta - Pharmaceuticals, 2022 - mdpi.com
Despite the scientific advancements, organophosphate (OP) poisoning continues to be a
major threat to humans, accounting for nearly one million poisoning cases every year …

[HTML][HTML] Spiropyran-based drug delivery systems

A Fagan, M Bartkowski, S Giordani - Frontiers in Chemistry, 2021 - frontiersin.org
Nanocarriers are rapidly growing in popularity in the field of drug delivery. The ability of
nanocarriers to encapsulate and distribute poorly soluble drugs while minimising their …

Big family of nano-and microscale drug delivery systems ranging from inorganic materials to polymeric and stimuli-responsive carriers as well as drug-conjugates

Z Shariatinia - Journal of Drug Delivery Science and Technology, 2021 - Elsevier
Traditional drug administration routs suffer from low selective distribution, poor solubility, fast
elimination and damaging adjacent healthy tissues (especially in cancer therapy). Thus …

Recent advances in oral nano-antibiotics for bacterial infection therapy

ZL Wu, J Zhao, R Xu - International Journal of Nanomedicine, 2020 - Taylor & Francis
Bacterial infections are the main infectious diseases and cause of death worldwide.
Antibiotics are used to treat various infections ranging from minor to life-threatening ones …

Unique insights into the intestinal absorption, transit, and subsequent biodistribution of polymer-derived microspheres

JJ Reineke, DY Cho, YT Dingle… - Proceedings of the …, 2013 - National Acad Sciences
Polymeric microspheres (MSs) have received attention for their potential to improve the
delivery of drugs with poor oral bioavailability. Although MSs can be absorbed into the …

[HTML][HTML] Physical characterization of clove oil based self Nano-emulsifying formulations of cefpodoxime proxetil: Assessment of dissolution rate, antioxidant & …

A Jindal, A Kumar - OpenNano, 2022 - Elsevier
Cefpodoxime proxetil (CPD) is a broad-spectrum cephalosporin widely indicated in
respiratory tract infections like pneumonia. CPD is a BCS class IV drug with the constraint of …

Nanosized liposomes containing bile salt: A vesicular nanocarrier for enhancing oral bioavailability of BCS class III drug

M Arafat, C Kirchhoefer, MM Mikov, MK Sarfraz… - 2017 - digitallibrary.aau.ac.ae
PURPOSE: Liposomes have been studied as a colloidal carrier in drug delivery systems,
especially for oral administration. However, their low structural integrity in the gut is still a …

Surface modification of PLGA nanoparticles with chitosan or Eudragit® RS 100: Characterization, prolonged release, cytotoxicity, and enhanced antimicrobial activity

G Yurtdaş-Kırımlıoğlu, Ş Görgülü - Journal of Drug Delivery Science and …, 2021 - Elsevier
Cefpodoxime proxetil (CEF) is a third-generation cephalosporin that is situated in BCS Class
II with poor oral bioavailability. In current work, poly (lactic-co-glycolide)(PLGA) …

[HTML][HTML] In Vitro and In Vivo Evaluations of Berberine-Loaded Microparticles Filled In-House 3D Printed Hollow Capsular Device for Improved Oral Bioavailability

D Choudhury, A Jala, US Murty, RM Borkar… - AAPS …, 2022 - Springer
The low oral bioavailability, short biological half-life, high dose, and frequent dosing of
berberine (BBR) contribute to its restricted clinical use despite its extensive pharmacological …

[HTML][HTML] Influence of copper-based fillers on structural and mechanical properties of polylactic acid composites

EE Mastalygina, AA Olkhov, NV Vorontsov… - Journal of Composites …, 2022 - mdpi.com
The importance of promising composites in modern materials science is constantly
increasing. The use of various fillers or additives is associated with their influence not only …