Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …

Investigations into the mixed muscle–secretory phenotype of cardiomyocytes from the atrial
appendages of the heart led to the discovery that these cells produce, in a regulated …

Despite an ever-growing prevalence and increasing economic burden of Alzheimer's
disease (AD) and Parkinson's disease (PD), recent advances in drug development have …

Microglia are brain-resident myeloid cells that mediate key functions to support the CNS.
Microglia express a wide range of receptors that act as molecular sensors, which recognize …

Alzheimer's disease is the most common form of dementia in the western world, however
there is no cure available for this devastating neurodegenerative disorder. Despite clinical …

Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

Microglia, the immune cells of the central nervous system, have long been a subject of study
in the Alzheimer's disease (AD) field due to their dramatic responses to the pathophysiology …

Alzheimer's disease (AD) is a devastating condition with no known effective treatment. AD is
characterized by memory loss as well as impaired locomotor ability, reasoning, and …

Expression of long-lasting synaptic plasticity and long-term memory requires protein
synthesis, which can be repressed by phosphorylation of eukaryotic initiation factor 2 α …

In the 12 years since the publication of the first Consensus Paper of the WFSBP on
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …