Transfection by means of non-viral gene delivery vectors is the cornerstone of modern gene
delivery. Despite the resources poured into the development of ever more effective …

Highlights•Cancer vaccines have a long history, but traditional protein/peptide antigens
have not had much success.•Nucleic acid vaccines based on either plasmid DNA or mRNA …

Intervention of the over-activated microglia-aggravated neuroinflammation represents a
promising therapeutic strategy for Alzheimer's disease (AD). Upregulation of triggering …

With the development of nanotechnology, various types of polymer-based drug delivery
systems have been designed for biomedical applications. Polymer-based drug delivery …

Polyamidoamine (PAMAM) dendrimers have been explored as an alternative to
polyethylenimine (PEI) as a gene delivery carrier because of their relatively low cytotoxicity …

Gene therapy has emerged as a promising tool for treating different intractable diseases,
particularly cancer or even viral diseases such as COVID‐19 (coronavirus disease 2019). In …

Oncolytic adenovirus (oAd) elicits antitumor activity by preferential viral replication in cancer
cells. However, poor systemic administrability or suboptimal intratumoral retainment of the …

Aim: This study aimed to develop phosphatase-responsive ζ potential converting
nanocarriers utilizing polyphosphate-coated cell-penetrating peptide (CPP)-decorated …

Background Gene therapy has held promises for treating specific genetic diseases.
However, the key to clinical application depends on effective gene delivery. Methods Using …

Background Cancer stem cells (CSCs) are responsible for cancer therapeutic resistance
and metastasis. To date, in addition to surgery, chemotherapy, and radiotherapy, gene …