Synaptotoxic amyloid-β oligomers: a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease?
WL Klein - Journal of Alzheimer's disease, 2013 - content.iospress.com
The oligomer hypothesis for Alzheimer's disease (AD) was introduced in 1998. It was based
on evidence that oligomers could exist free of amyloid fibrils, that fibril-free oligomer …
on evidence that oligomers could exist free of amyloid fibrils, that fibril-free oligomer …
A gating mutation in ryanodine receptor type 2 rescues phenotypes of Alzheimer's disease mouse models by upregulating neuronal autophagy
H Zhang, C Knight, SRW Chen… - Journal of …, 2023 - Soc Neuroscience
It is well established that ryanodine receptors (RyanRs) are overactive in Alzheimer's
disease (AD), and it has been suggested that inhibition of RyanR is potentially beneficial for …
disease (AD), and it has been suggested that inhibition of RyanR is potentially beneficial for …
Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function
Mutation in the SHANK3 human gene leads to different neuropsychiatric diseases including
Autism Spectrum Disorder (ASD), intellectual disabilities and Phelan-McDermid syndrome …
Autism Spectrum Disorder (ASD), intellectual disabilities and Phelan-McDermid syndrome …
The dendritic hypothesis for Alzheimer's disease pathophysiology
JN Cochran, AM Hall, ED Roberson - Brain research bulletin, 2014 - Elsevier
Converging evidence indicates that processes occurring in and around neuronal dendrites
are central to the pathogenesis of Alzheimer's disease. These data support the concept of a …
are central to the pathogenesis of Alzheimer's disease. These data support the concept of a …
Reduced prevalence of dementia in patients prescribed tacrolimus, sirolimus, or cyclosporine
JD Silva, G Taglialatela… - Journal of Alzheimer's …, 2023 - content.iospress.com
Background: Evidence suggests patients prescribed calcineurin inhibitors (CNIs) have a
reduced prevalence of dementia, including Alzheimer's disease (AD); however, this result …
reduced prevalence of dementia, including Alzheimer's disease (AD); however, this result …
EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques
Alzheimer's disease (AD) is characterized by the transition of amyloid-β (Aβ) monomers into
toxic oligomers and plaques. Given that Aβ abnormality typically precedes the development …
toxic oligomers and plaques. Given that Aβ abnormality typically precedes the development …
A role for calcineurin in Alzheimer's disease
LC Reese, G Taglialatela - Current neuropharmacology, 2011 - ingentaconnect.com
Alzheimer's disease (AD) is an incurable age-related neurodegenerative disorder
characterized by profound memory dysfunction. This bellwether symptom suggests …
characterized by profound memory dysfunction. This bellwether symptom suggests …
The emerging role of peptidyl‐prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease
Peptidyl‐prolyl cis/trans isomerases (PPI ases), a unique family of molecular chaperones,
regulate protein folding at proline residues. These residues are abundant within intrinsically …
regulate protein folding at proline residues. These residues are abundant within intrinsically …
Identifying new substrates and functions for an old enzyme: calcineurin
J Roy, MS Cyert - Cold Spring Harbor Perspectives in …, 2020 - cshperspectives.cshlp.org
Biological processes are dynamically regulated by signaling networks composed of protein
kinases and phosphatases. Calcineurin, or PP3, is a conserved phosphoserine …
kinases and phosphatases. Calcineurin, or PP3, is a conserved phosphoserine …
Protein phosphatases and Alzheimer's disease
SP Braithwaite, JB Stock, PJ Lombroso… - Progress in molecular …, 2012 - Elsevier
Alzheimer's Disease (AD) is characterized by progressive loss of cognitive function, linked to
marked neuronal loss. Pathological hallmarks of the disease are the accumulation of the …
marked neuronal loss. Pathological hallmarks of the disease are the accumulation of the …