Expression of TMEM16A protein is associated with the activity of Ca 2+-activated Cl−
channels. TMEM16A primary transcript undergoes alternative splicing. thus resulting in the …

Key Points• Chloride channels are important for proper hydration of the airway surface.•
TMEM16A protein is an important component of calcium‐activated chloride channels.• …

▪ Abstract The physical removal of viruses and bacteria on the mucociliary escalator is an
important aspect of the mammalian lung's innate defense mechanism. The volume of airway …

Mucus clearance is an important component of the lung's innate defense against disease,
and the ability of the airways to clear mucus is strongly dependent on the volume of liquid on …

Calcium-activated chloride channels (CaCCs) are widely expressed in various tissues and
implicated in physiological processes such as sensory transduction, epithelial secretion, and …

Background Long-term benefits of newborn screening (NBS) for cystic fibrosis (CF) have
been established with respect to nutritional status, but effects on pulmonary health remain …

The Tmem16 gene family was first identified by bioinformatic analysis in 2004. In 2008, it
was shown independently by 3 laboratories that the first two members (Tmem16A and …

SCN−(thiocyanate) is an important physiological anion involved in innate defense of
mucosal surfaces. SCN− is oxidized by H 2 O 2, a reaction catalyzed by lactoperoxidase, to …

Update on pathogenesis of cystic fibrosis lung disease : Current Opinion in Pulmonary
Medicine Update on pathogenesis of cystic fibrosis lung disease : Current Opinion in …

Calcium-activated chloride channels (CaCCs) participate in many different physiologic
processes such as transepithelial transport, excitability of neurons and muscle cells, and …