[HTML][HTML] Regulation of TMEM16A chloride channel properties by alternative splicing
L Ferrera, A Caputo, I Ubby, E Bussani… - Journal of Biological …, 2009 - ASBMB
Expression of TMEM16A protein is associated with the activity of Ca 2+-activated Cl−
channels. TMEM16A primary transcript undergoes alternative splicing. thus resulting in the …
channels. TMEM16A primary transcript undergoes alternative splicing. thus resulting in the …
Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia
Key Points• Chloride channels are important for proper hydration of the airway surface.•
TMEM16A protein is an important component of calcium‐activated chloride channels.• …
TMEM16A protein is an important component of calcium‐activated chloride channels.• …
Regulation of normal and cystic fibrosis airway surface liquid volume by phasic shear stress
▪ Abstract The physical removal of viruses and bacteria on the mucociliary escalator is an
important aspect of the mammalian lung's innate defense mechanism. The volume of airway …
important aspect of the mammalian lung's innate defense mechanism. The volume of airway …
Regulation of airway surface liquid volume and mucus transport by active ion transport
R Tarran - Proceedings of the American Thoracic Society, 2004 - atsjournals.org
Mucus clearance is an important component of the lung's innate defense against disease,
and the ability of the airways to clear mucus is strongly dependent on the volume of liquid on …
and the ability of the airways to clear mucus is strongly dependent on the volume of liquid on …
International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels
F Huang, X Wong, LY Jan - Pharmacological reviews, 2012 - ASPET
Calcium-activated chloride channels (CaCCs) are widely expressed in various tissues and
implicated in physiological processes such as sensory transduction, epithelial secretion, and …
implicated in physiological processes such as sensory transduction, epithelial secretion, and …
Lung function is abnormal in 3-month-old infants with cystic fibrosis diagnosed by newborn screening
AF Hoo, LP Thia, A Bush, J Chudleigh, S Lum… - Thorax, 2012 - thorax.bmj.com
Background Long-term benefits of newborn screening (NBS) for cystic fibrosis (CF) have
been established with respect to nutritional status, but effects on pulmonary health remain …
been established with respect to nutritional status, but effects on pulmonary health remain …
[HTML][HTML] Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?
C Duran, H Hartzell - Acta pharmacologica Sinica, 2011 - nature.com
The Tmem16 gene family was first identified by bioinformatic analysis in 2004. In 2008, it
was shown independently by 3 laboratories that the first two members (Tmem16A and …
was shown independently by 3 laboratories that the first two members (Tmem16A and …
Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels
N Pedemonte, E Caci, E Sondo, A Caputo… - The Journal of …, 2007 - journals.aai.org
SCN−(thiocyanate) is an important physiological anion involved in innate defense of
mucosal surfaces. SCN− is oxidized by H 2 O 2, a reaction catalyzed by lactoperoxidase, to …
mucosal surfaces. SCN− is oxidized by H 2 O 2, a reaction catalyzed by lactoperoxidase, to …
Update on pathogenesis of cystic fibrosis lung disease
SH Donaldson, RC Boucher - Current opinion in pulmonary …, 2003 - journals.lww.com
Update on pathogenesis of cystic fibrosis lung disease : Current Opinion in Pulmonary
Medicine Update on pathogenesis of cystic fibrosis lung disease : Current Opinion in …
Medicine Update on pathogenesis of cystic fibrosis lung disease : Current Opinion in …
Calcium-activated Chloride Channels: (Un) known,(Un) loved?
J Eggermont - Proceedings of the American Thoracic Society, 2004 - atsjournals.org
Calcium-activated chloride channels (CaCCs) participate in many different physiologic
processes such as transepithelial transport, excitability of neurons and muscle cells, and …
processes such as transepithelial transport, excitability of neurons and muscle cells, and …