Members of the Anoctamin (Ano)/TMEM16A family have recently been identified as
essential subunits of the Ca 2+-activated chloride channel (CaCC). For example, Ano1 is …

CLCA proteins were discovered in bovine trachea and named for a calcium-dependent
chloride conductance found in trachea and in other secretory epithelial tissues. At least four …

Ivacaftor use can lead to dramatic health improvements in cystic fibrosis (CF) patients with
gating mutations. Here, we report five instances of dramatic clinical decline following …

Ion transport is essential for maintenance of transmembranous and transcellular electric
potential, fluid transport and cellular volume. Disturbance of ion transport has been …

Normal airways homeostatically regulate the volume of airway surface liquid (ASL) through
both cAMP-and Ca2+-dependent regulation of ion and water transport. In cystic fibrosis (CF) …

Background & Aims: Deletion of the codon for phenylalanine at position 508 (ΔF508) is the
most frequent disease-causing mutation in the cystic fibrosis transmembrane conductance …

Highlights•Common airway diseases including COPD, asthma and non-CF bronchiectasis
(NCFBE) share the common pathophysiologic feature of mucus obstruction.•Acquired CFTR …

Cystic fibrosis (CF), a multiorgan genetic disease, is caused by loss of function of CFTR, a
cAMP-regulated anion channel. In CF airway epithelia, defective Cl− and bicarbonate …

The cystic fibrosis transmembrane conductance regulator CFTR gene is found on
chromosome 7 [Kerem, B., Rommens, JM, Buchanan, JA, Markiewicz, D., Cox, TK …

purpose. To define the role of the cystic fibrosis transmembrane conductance regulator
(CFTR) in Cl− secretion at the mouse ocular surface in vivo. methods. Open-circuit potential …