Rationale: Cystic fibrosis (CF) airways disease produces a mucoobstructive lung phenotype
characterized by airways mucus plugging, epithelial mucous cell metaplasia/hyperplasia …

Ca-activated Cl channels are an important component of olfactory transduction. Odor
binding to olfactory receptors in the cilia of olfactory sensory neurons (OSNs) leads to an …

Cystic fibrosis (CF), the most common life-shortening genetic disorder in Caucasians, affects
approximately 70 000 individuals worldwide. In 1998, the Cystic Fibrosis Foundation (CFF) …

Various human tissues express the calcium-activated chloride channel Anoctamin 1 (ANO1),
also known as TMEM16A. ANO1 allows the passive chloride flux that controls different …

Cystic fibrosis (CF) lung disease is characterized by persistent airway inflammation and
airway infection that ultimately leads to respiratory failure. Aspergillus sp. are present in the …

Anatomical proximity and functional correlations between the exocrine and endocrine
pancreas warrant reciprocal effects between the two parts. Inflammatory diseases of the …

A non‐genomic antisecretory role for dexamethasone at low concentrations (0.1 nm to1 μm)
is described in monolayers of human bronchial epithelial cells in primary culture and in a …

The ability to regulate cell volume is crucial for normal physiology; equally the regulation of
extracellular fluid homeostasis is of great importance. Alteration of normal extracellular fluid …

Abstract The Ca2+-activated Cl− channel (CaCC) TMEM16A/Anoctamin 1 (ANO1) is
expressed in gastrointestinal epithelia and smooth muscle cells where it mediates secretion …

The composition and depth of the airway surface liquid (ASL) are key parameters in airway
physiology that are thought to be important in the pathophysiology of cystic fibrosis and other …