Chronic obstructive pulmonary disease is a common cause of morbidity and a rising cause
of mortality worldwide. Its rising impact indicates the ongoing unmet need for novel and …

The cystic fibrosis transmembrane conductance regulator (CFTR) plays a crucial role in
regulating fluid secretion by the airways, intestines, sweat glands and other epithelial …

Ca2+ activated Cl− transport is found in airways and other organs and is abnormal in cystic
fibrosis, polycystic kidney disease and infectious diarrhea. The molecular identity of Ca2+ …

Electrogenic sodium-dependent glucose transport along the length of the intestine was
compared between the omnivorous Nile tilapia (Oreochromis niloticus) and the carnivorous …

The transmembrane protein TMEM16A forms a Ca2+-activated Cl− channel that is
permeable to many anions, including SCN−, I−, Br−, Cl−, and HCO3−, and has been …

Defective epithelial chloride secretion occurs in humans with cystic fibrosis (CF), a genetic
defect due to loss of function of CFTR, a cAMP-activated chloride channel. In the airways …

Two fundamental mechanisms within alveoli are essential for lung function: regulated fluid
transport and secretion of surfactant. Surfactant is secreted via exocytosis of lamellar bodies …

Cystic fibrosis is caused by dysfunction of the cystic fibrosis transmembrane conductance
regulator (CFTR) protein, leading to altered ion transport, chronic infection, and excessive …

Vertebrates can sense and avoid noxious heat that evokes pain. Many thermoTRP channels
are associated with temperature sensation. TRPV1 is a representative ion channel that is …

Although small airways account for the largest fraction of the total conducting airway
surfaces, the epithelial fluid and electrolyte transport in small, native airway epithelia has not …