Adenosine (ADO) signaling is altered in both asthma and chronic obstructive pulmonary
disease, and the A2B adenosine receptor (A2B-R) may drive pulmonary inflammation …

Abstract Ca2+‐activated Cl− channels (CaCCs) are plasma membrane proteins involved in
various important physiological processes. In epithelial cells, CaCC activity mediates the …

The effects of CLCA protein expression on the regulation of Cl− conductance by intracellular
Ca2+ and cAMP have been studied previously in nonepithelial cell lines chosen for low …

Ca2+-activated Cl− channels (CaCCs) contribute to airway Cl− and fluid secretion, and were
implicated in the modulation of disease severity and as a therapeutic target in cystic fibrosis …

The pathophysiology of obstructive pulmonary diseases, such as cystic fibrosis (CF), leads
to the development of chronic infections in the respiratory tract. Thus, the symptomatic …

Salt and fluid absorption is a shared function of many of the body's epithelia, but its use is
highly adapted to the varied physiological roles of epithelia-lined organs. These functions …

Adenosine is formed from extracellular purines by ecto-5′-nucleotidase (CD73) and is an
essential player in allergic airway inflammation. The contribution of adenosine and other …

Understanding the development of lung disease in cystic fibrosis (CF) has been a sought
after goal for several decades. With the cloning of the CF transmembrane conductance …

Kinetic characterization of electrogenic sodium‐dependent transport in Ussing chambers of
d‐glucose and d‐galactose demonstrated sigmoidal/Hill kinetics in the porcine jejunum and …

Transport of water and electrolytes in airway epithelia involves chloride‐selective ion
channels, which are controlled either by cytosolic Ca2+ or by cAMP. The contributions of the …