Adenosine (Ado) regulates diverse cellular functions in the lung through its local production,
release, metabolism, and subsequent stimulation of G-protein-coupled P1 purinergic …

Cystic fibrosis (CF) is one of the most common lethal autosomal recessive genetic diseases
in the Caucasian population, with a frequency of about 1 in 3000 livebirths. CF is due to a …

Prolonged heat and sea salt aerosols pose a challenge for the mammalian airway, placing
the protective airway surface liquid (ASL) at risk for desiccation. Thus, mammals inhabiting …

Ion channels are potentially exploitable as pharmacological targets to treat asthma. This
study evaluated the role of KCa3. 1 channels, encoded by Kcnn4, in regulating the gene …

Haemolysin (VMH) is a virulent factor produced by Vibrio mimicus, a human pathogen that
causes diarrhoea. As intestinal epithelial cells are the primary targets of haemolysin, we …

Cystic fibrosis (CF) was one of the first inherited disorders for which gene therapy was
seriously considered as a realistic option for treatment, and as such, it has long provided a …

Cystic fibrosis (CF) results from the absence or dysfunction of a single protein, the CF
transmembrane conductance regulator (CFTR). CFTR plays a critical role in the regulation of …

The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel
responsible for the direct transport of bicarbonate and chloride. CFTR-dependent ionic …

Chronic lung diseases are prevalent worldwide and cause significant mortality and suffering.
This article discusses infections that occur in three chronic lung diseases: chronic …

A new aspect of research into the pathogenesis of cystic fibrosis (CF) is a genetics-based
search formodifier genes' that may affect the severity of CF lung disease. Using an …