Background In many developed countries, the workforce is rapidly aging. Occupational
demands however, have not decreased despite the fact that workers see a decline in …

More than 200 million people are affected by osteoporosis worldwide, as estimated by 2
million annual hip fractures and other debilitating bone fractures (vertebrae compression …

The Bioarchaeology of Metabolic Bone Disease, Second Edition is a comprehensive source
dedicated to better understanding this group of conditions that have significant …

Bone mineral density (BMD), a diagnostic parameter for osteoporosis and a clinical predictor
of fracture, is a polygenic trait with high heritability. To identify genetic variants that influence …

A decrease in genomic methylation commonly occurs in aging cells; however, whether this
epigenetic modification leads to age-related phenotypes has not been evaluated. Alu …

The detection of single nucleotide polymorphisms (SNPs) is of increasing importance in
many areas including clinical diagnostics, patient stratification for pharmacogenomics, and …

Osteoporosis affects nearly 10 million individuals in the United States. Conventional
treatments include anti-resorptive drug therapies, but recently, it has been demonstrated that …

Osteoporosis is a severe chronic skeletal disorder that affects older individuals, especially
postmenopausal women. However, molecular biomarkers for predicting the risk of …

Hydroxyapatite is chemically related to the inorganic component of bone matrix as a
complex structure with the formula of Ca10 (OH) 2 (PO4) 6. Previous studies have reported …

Objective Osteoporosis and obesity are complex diseases with a strong genetic component.
Bone mineral density (BMD) and body mass index (BMI) linkage studies identified a locus at …