For many years, the vast amount of data gathered from analysis of nonobese diabetic (NOD)
and congenic NOD mice has eclipsed interest in the rat for the study of type 1 diabetes. The …

The establishment and maintenance of immunological tolerance entails both central and
peripheral mechanisms. The latter have been highlighted in the past several years, mostly …

The induction of operational immune tolerance is a major goal in beta-cell replacement
strategies for the treatment of type 1 diabetes. Our group previously reported long-term …

OBJECTIVE To create an immunodeficient mouse model that spontaneously develops
hyperglycemia to serve as a diabetic host for human islets and stem cell–derived β-cells in …

Aims/Hypothesis Inhibition of PD1-PDL1 signaling in NOD mice accelerates onset of type 1
diabetes implicating this pathway in suppressing the emergence of pancreatic beta cell …

Autoimmune disease has presented an insurmountable barrier to restoration of durable
immune tolerance. Previous studies indicate that chronic therapy with metabolic inhibitors …

Type 1 diabetes (T1D) is characterized by the destruction of the insulin-producing β-cells of
pancreatic islets. Genetic and environmental factors both contribute to T1D development …

Although type 1 diabetes cannot be prevented or reversed, replacement of insulin
production by transplantation of the pancreas or pancreatic islets represents a definitive …

Curing type 1 diabetes by islet transplantation requires overcoming both allorejection and
recurrent autoimmunity. This has been achieved with systemic immunosuppression, but …

Allogeneic hematopoietic chimerism leading to central tolerance has significant therapeutic
potential. Realization of that potential has been impeded by the need for myeloablative …