BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

The mammalian ovary is an extremely dynamic organ in which a large majority of follicles
are effectively eliminated throughout their reproductive life. Due to the numerous efforts of …

Phthalates are commonly used as plasticizers in the manufacturing of flexible polyvinyl
chloride products. Large production volumes of phthalates and their widespread use in …

Oogenesis is a complex process regulated by a vast number of intra-and extra-ovarian
factors. Oogonia, which originate from primordial germ cells, proliferate by mitosis and form …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

A basic doctrine of reproductive biology is that most mammalian females lose the capacity
for germ-cell renewal during fetal life, such that a fixed reserve of germ cells (oocytes) …

Premature ovarian insufficiency (POI) is one form of female infertility, defined by loss of
ovarian activity before the age of 40 and characterized by amenorrhea (primary or …

Accurate estimation of the number of ovarian follicles at various stages of development is an
important indicator of the process of folliculogenesis in relation to the endocrine signals and …

In many organisms, early germline development takes place within cysts of interconnected
cells that form by incomplete cytokinesis and later undergo programmed breakdown. We …

Each cell is under constant surveillance to maintain the integrity of its genome. Genomic
lesions in a cell must be repaired before the onset of DNA replication and cell division. In the …