By integrating morphometrical and endocrinological data, as well as biological effects of
various molecules synthesized by the human follicle, we propose a dynamic view of the …

The differentiation of primordial germ cells (PGCs) into functional oocytes is important for the
continuation of species. In mammals, PGCs begin to differentiate into oocytes during …

Female mammals are endowed with a finite number of oocytes at birth, each enclosed by a
single layer of somatic (granulosa) cells in a primordial follicle 1, 2. The fate of most follicles …

For decades, the mechanisms responsible for germ cell depletion from the ovary, either
directly during the perinatal period or indirectly via follicular atresia during postnatal life …

All metazoans that reproduce sexually have the ability to form gametes. Both types of
gametes, the egg and the sperm, arise from germ cells, undergo a unique program of …

The creation of the pool of follicles available for selection and ovulation is a multi-faceted,
tightly regulated process that spans the period from embryonic development through to the …

Female sterility resulting from oocyte destruction is an unfortunate, and in many cases
inevitable, consequence of chemotherapy. We show that unfertilized mouse oocytes …

Bcl-2 is the prototype of a class of oncogenes which regulates apoptosis. Bcl-2-related gene
products with either death-promoting and death-inhibitory activity are critically involved in …

Apoptosis is a critical process for regulating both the size and the quality of the male and
female germ lines. In this review, we examine the importance of this process during …

Background Many investigations have reported that mesenchymal stem cell (MSC)
transplantation can ameliorate the structure and function of injured tissues. The purpose of …