Prenatal oogenesis produces hundreds of thousands of oocytes, most of which are
discarded through apoptosis before birth. Despite this large-scale selection, the survivors do …

Objectives: Correlations between parental age, aneuploidy in germ cells and recent findings
on aetiological factors in mammalian trisomy formation are reviewed. Methods: Data from …

Oogenesis is essential for female gamete production in mammals. The total number of
ovarian follicles is determined early in life and production of ovarian oocytes is thought to …

Abstract Studies have shown that 2, 5-hexanedione (2, 5-HD) is the main active metabolite
of n-hexane in the human body. The toxicity of n-hexane and 2, 5-hexanedione has been …

The Bcl-2 gene family regulates tissuedevelopment and tissue homeostasis through the
interplayof survival and death factors. Family members arecharacterized as either pro …

Background Breast cancer in young women is typically characterised by aggressive
disease, and treatment with adjuvant chemotherapy is generally recommended …

The mammalian ovarian reserve is comprised of a finite pool of primordial follicles,
representing the lifetime reproductive capacity of females. In most mammals, the reserve is …

Since the cloning of the bcl-2 gene in 1985, considerable progress has been made in
elucidating the function of Bcl-2 and related proteins in controlling apoptosis. Although much …

In most female mammals, early germline development begins with the appearance of
primordial germ cells (PGCs), and develops to form mature oocytes following several vital …

Programmed cell death or apoptosis is an essential component of human ovarian function
and development. During early fetal life approximately 7× 106 oocytes are formed in the …