Immunomodulatory hydrogels: advanced regenerative tools for diabetic foot ulcer
Y Xiong, Q Feng, L Lu, K Zha, T Yu, Z Lin… - Advanced Functional …, 2023 - Wiley Online Library
Diabetic foot ulcer (DFU) is one of the most common complications of diabetes, bringing
physical and mental challenges for patients due to the lack of efficient curative therapy …
physical and mental challenges for patients due to the lack of efficient curative therapy …
The diversification of methods for studying cell–cell interactions and communication
No cell lives in a vacuum, and the molecular interactions between cells define most
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …
TISCH2: expanded datasets and new tools for single-cell transcriptome analyses of the tumor microenvironment
Abstract The Tumor Immune Single Cell Hub 2 (TISCH2) is a resource of single-cell RNA-
seq (scRNA-seq) data from human and mouse tumors, which enables comprehensive …
seq (scRNA-seq) data from human and mouse tumors, which enables comprehensive …
Defining and using immune archetypes to classify and treat cancer
Tumours are surrounded by a host immune system that can suppress or promote tumour
growth. The tumour microenvironment (TME) has often been framed as a singular entity …
growth. The tumour microenvironment (TME) has often been framed as a singular entity …
Aging and wound healing of the skin: a review of clinical and pathophysiological hallmarks
Aging is a universal process that can cause diminished function of organs and various
diseases. The most striking consequences of aging can be seen visibly on the skin, which …
diseases. The most striking consequences of aging can be seen visibly on the skin, which …
[HTML][HTML] Transcriptional space-time mapping identifies concerted immune and stromal cell patterns and gene programs in wound healing and cancer
Tissue repair responses in metazoans are highly coordinated by different cell types over
space and time. However, comprehensive single-cell-based characterization covering this …
space and time. However, comprehensive single-cell-based characterization covering this …
CellChat for systematic analysis of cell-cell communication from single-cell and spatially resolved transcriptomics
Recent advances in single-cell sequencing technologies offer an opportunity to explore cell-
cell communication in tissues systematically and with reduced bias. A key challenge is the …
cell communication in tissues systematically and with reduced bias. A key challenge is the …
Biomarkers of aging
Aging Biomarker Consortium, H Bao, J Cao… - Science China Life …, 2023 - Springer
Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …
WNT-dependent interaction between inflammatory fibroblasts and FOLR2+ macrophages promotes fibrosis in chronic kidney disease
Chronic kidney disease (CKD) is a public health problem driven by myofibroblast
accumulation, leading to interstitial fibrosis. Heterogeneity is a recently recognized …
accumulation, leading to interstitial fibrosis. Heterogeneity is a recently recognized …
Human umbilical cord mesenchymal stem cell-derived exosomes promote murine skin wound healing by neutrophil and macrophage modulations revealed by single …
Y Liu, M Zhang, Y Liao, H Chen, D Su, Y Tao… - Frontiers in …, 2023 - frontiersin.org
Introduction Full-thickness skin wound healing remains a serious undertaking for patients.
While stem cell-derived exosomes have been proposed as a potential therapeutic approach …
While stem cell-derived exosomes have been proposed as a potential therapeutic approach …