Immunometabolism, which is the metabolic reprogramming of anaerobic glycolysis,
oxidative phosphorylation, and metabolite synthesis upon immune cell activation, has …

Kidney tubular epithelial cells (TECs) have a crucial role in the damage and repair response
to acute and chronic injury. To adequately respond to constant changes in the environment …

INTRODUCTION Innate immunity relies on several families of pattern recognition molecules
(PRMs) that broadly recognize microbial motifs and danger signals. Upon activation …

Pattern recognition receptors (PRR), such as NOD-like receptors (NLRs), sense conserved
microbial signatures, and host danger signals leading to the coordination of appropriate …

In physiological settings, the complement protein C3 is deposited on all bacteria, including
invasive pathogens. However, because experimental host-bacteria systems typically use …

NLRX1 is a member of the NOD‐like receptor family, a set of pattern recognition receptors
associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its …

Background & Aims The gastrointestinal syndrome is an illness of the intestine caused by
high levels of radiation. It is characterized by extensive loss of epithelial tissue integrity …

Background & Aims Fiber-rich foods promote health, but mechanisms by which they do so
remain poorly defined. Screening fiber types, in mice, revealed psyllium had unique ability to …

Activation of innate immunity is essential for host cells to restrict the spread of invading
viruses and other pathogens. However, attenuation or termination of signaling is also …

NLRX1 is a member of the of the Nod-like receptor (NLR) family, and it represents a unique
pattern recognition molecule (PRM) as it localizes to the mitochondrial matrix in resting …