Preparation of von Hippel-Lindau (VHL) E3 ubiquitin ligase ligands exploiting constitutive hydroxyproline for benzylic amine protection
DM Soto-Martínez, GD Clements, JE Díaz, J Becher… - RSC …, 2024 - pubs.rsc.org
The von Hippel-Lindau (VHL) protein serves as the substrate recognition subunit of the multi-
subunit Cullin-2 RING E3 ubiquitin ligase (CRL2VHL), which regulates intracellular …
subunit Cullin-2 RING E3 ubiquitin ligase (CRL2VHL), which regulates intracellular …
Non-Markovian Dynamic Models Identify Non-Canonical KRAS-VHL Encounter Complex Conformations for Novel PROTAC Design
Targeted protein degradation (TPD) is emerging as a promising therapeutic approach for
cancer and other diseases, with an increasing number of programs demonstrating its …
cancer and other diseases, with an increasing number of programs demonstrating its …