Concussion as a multi-scale complex system: an interdisciplinary synthesis of current knowledge

ES Kenzie, EL Parks, ED Bigler, MM Lim… - Frontiers in …, 2017 - frontiersin.org
Traumatic brain injury (TBI) has been called “the most complicated disease of the most
complex organ of the body” and is an increasingly high-profile public health issue. Many …

White matter and cognition in traumatic brain injury

CM Filley, JP Kelly - Journal of Alzheimer's Disease, 2018 - content.iospress.com
Traumatic brain injury (TBI) is a leading cause of disability and produces a wide range of
cognitive, emotional, and physical consequences. The impact of TBI on cognition is among …

The evolution of white matter microstructural changes after mild traumatic brain injury: a longitudinal DTI and NODDI study

EM Palacios, JP Owen, EL Yuh, MB Wang… - Science …, 2020 - science.org
Neuroimaging biomarkers that can detect white matter (WM) pathology after mild traumatic
brain injury (mTBI) and predict long-term outcome are needed to improve care and develop …

Diffusion tensor imaging reveals elevated diffusivity of white matter microstructure that is independently associated with long-term outcome after mild traumatic brain …

EM Palacios, EL Yuh, CL Mac Donald… - Journal of …, 2022 - liebertpub.com
Diffusion tensor imaging (DTI) literature on single-center studies contains conflicting results
regarding acute effects of mild traumatic brain injury (mTBI) on white matter (WM) …

The dynamics of concussion: mapping pathophysiology, persistence, and recovery with causal-loop diagramming

ES Kenzie, EL Parks, ED Bigler, DW Wright… - Frontiers in …, 2018 - frontiersin.org
Despite increasing public awareness and a growing body of literature on the subject of
concussion, or mild traumatic brain injury, an urgent need still exists for reliable diagnostic …

Early versus late profiles of inflammatory cytokines after mild traumatic brain injury and their association with neuropsychological outcomes

A Vedantam, J Brennan, HS Levin… - Journal of …, 2021 - liebertpub.com
Despite pre-clinical evidence for the role of inflammation in traumatic brain injury (TBI), there
is limited data on inflammatory biomarkers in mild TBI (mTBI). In this study, we describe the …

A pre-existing Toxoplasma gondii infection exacerbates the pathophysiological response and extent of brain damage after traumatic brain injury in mice

TL Baker, DK Wright, AD Uboldi, CJ Tonkin… - Journal of …, 2024 - Springer
Traumatic brain injury (TBI) is a key contributor to global morbidity that lacks effective
treatments. Microbial infections are common in TBI patients, and their presence could modify …

Current trends in biomarker discovery and analysis tools for traumatic brain injury

BI Martinez, SE Stabenfeldt - Journal of biological engineering, 2019 - Springer
Traumatic brain injury (TBI) affects 1.7 million people in the United States each year, causing
lifelong functional deficits in cognition and behavior. The complex pathophysiology of neural …

Brain correlates of subjective cognitive complaints in COVID-19 survivors: A multimodal magnetic resonance imaging study

M Paolini, M Palladini, MG Mazza, F Colombo… - European …, 2023 - Elsevier
Cognitive impairment represents a leading residual symptom of COVID-19 infection, which
lasts for months after the virus clearance. Up-to-date scientific reports documented a wide …

White matter alterations in military service members with remote mild traumatic brain injury

S Kim, J Ollinger, C Song, S Raiciulescu… - JAMA network …, 2024 - jamanetwork.com
Importance Mild traumatic brain injury (mTBI) is the signature injury experienced by military
service members and is associated with poor neuropsychiatric outcomes. Yet, there is a lack …