Macrophages are among the first cellular actors facing the invasion of microorganisms.
These cells are able to internalize pathogens and destroy them by means of toxic mediators …

BACKGROUND: Protozoan parasites of the genus Leishmania cause a number of important
diseases in humans and undergo a complex life cycle, alternating between a sand fly vector …

Amphibian skin secretions are considered a rich source of biologically active compounds
and are known to be rich in peptides, bufadienolides and alkaloids. Bufadienolides are …

Diffuse cutaneous leishmaniasis (DCL) is a rare clinical manifestation of tegumentary
leishmaniasis. The molecular mechanisms underlying DCL pathogenesis remain unclear …

Leukotrienes (LTs) are known to be produced by macrophages when challenged with
Leishmania, but it is not known whether these lipid mediators play a role in host defense …

The protozoan parasite Leishmania spp. exists as extracellular promastigotes in its vector
whereas it resides and replicates as amastigotes within the macrophages of its mammalian …

The murine models of Leishmania infection are well-studied and suitable models for
studying this disease, which, despite its incidence of nearly 2 million new cases worldwide …

The purinergic P2X7 receptor is a membrane protein of leucocytes involved in the clearance
of intracellular bacteria such as Chlamydia and Mycobacterium. In this work, we investigated …

Tetradenia riparia plant is used as a traditional medicine in Africa for the treatment of
inflammatory and infectious diseases as like parasitic. Therapy for leishmaniasis caused by …

Abstract Background Nitric oxide (NO•) plays a pivotal role as a leishmanicidal agent in
mouse macrophages. NO• resistant Escherichia coli and Mycobacterium tuberculosis have …