An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …

The direct (eg, radiation, microgravity) and indirect (eg, lifestyle perturbations) effects of
spaceflight extend across multiple systems resulting in whole-organism cardiovascular …

Many strategies have been adopted to construct in vitro myocardium models, which are of
great value to both drug cardiotoxicity evaluation and cardiovascular drug development. In …

Cardiomyopathies (CMPs) represent a significant healthcare burden and are a major cause
of heart failure leading to premature death. Several CMPs are now recognized to have a …

Optical mapping is a powerful imaging technique widely adopted to measure membrane
potential changes and intracellular Ca2+ variations in excitable tissues using voltage …

Purpose 4D fabrication techniques have been utilized for advanced biomedical therapeutics
due to their ability to create dynamic constructs that can transform into desired shapes on …

Cardiovascular disease (CVD) has become a severe threat to human health, with morbidity
and mortality increasing yearly and gradually becoming younger. When the disease …

Current methods to generate cardiomyocytes from induced pluripotent stem cells (iPSc)
utilize broad-spectrum pharmacological inhibitors. These methods give rise to …

Human induced pluripotent stem cell (iPSC) platforms are valuable for biomedical and
pharmaceutical research by providing tissue-specific human cells that retain patients' …

Background Although human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-
CMs) are a promising cell resource for cardiovascular research, these cells exhibit an …