Multiscale cancer modeling
TS Deisboeck, Z Wang, P Macklin… - Annual review of …, 2011 - annualreviews.org
Simulating cancer behavior across multiple biological scales in space and time, ie,
multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine …
multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine …
Simulating cancer growth with multiscale agent-based modeling
Z Wang, JD Butner, R Kerketta, V Cristini… - Seminars in cancer …, 2015 - Elsevier
There have been many techniques developed in recent years to in silico model a variety of
cancer behaviors. Agent-based modeling is a specific discrete-based hybrid modeling …
cancer behaviors. Agent-based modeling is a specific discrete-based hybrid modeling …
Cancer systems biology: a network modeling perspective
PK Kreeger, DA Lauffenburger - Carcinogenesis, 2010 - academic.oup.com
Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …
type and tissue origin but also as a disease involving dysregulation of multiple pathways …
A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition
C Gong, O Milberg, B Wang, P Vicini… - Journal of the …, 2017 - royalsocietypublishing.org
When the immune system responds to tumour development, patterns of immune infiltrates
emerge, highlighted by the expression of immune checkpoint-related molecules such as …
emerge, highlighted by the expression of immune checkpoint-related molecules such as …
Mathematical models of tumor cell proliferation: A review of the literature
AM Jarrett, EABF Lima, DA Hormuth… - Expert review of …, 2018 - Taylor & Francis
Introduction: A defining hallmark of cancer is aberrant cell proliferation. Efforts to understand
the generative properties of cancer cells span all biological scales: from genetic deviations …
the generative properties of cancer cells span all biological scales: from genetic deviations …
Multi-scale modelling and simulation in systems biology
JO Dada, P Mendes - Integrative Biology, 2011 - academic.oup.com
The aim of systems biology is to describe and understand biology at a global scale where
biological functions are recognised as a result of complex mechanisms that happen at …
biological functions are recognised as a result of complex mechanisms that happen at …
Three-dimensional in vitro cancer models: a short review
C Wang, Z Tang, Y Zhao, R Yao, L Li, W Sun - Biofabrication, 2014 - iopscience.iop.org
The re-creation of the tumor microenvironment including tumor–stromal interactions, cell–
cell adhesion and cellular signaling is essential in cancer-related studies. Traditional two …
cell adhesion and cellular signaling is essential in cancer-related studies. Traditional two …
Toward predictive multiscale modeling of vascular tumor growth: computational and experimental oncology for tumor prediction
JT Oden, EABF Lima, RC Almeida, Y Feng… - … Methods in Engineering, 2016 - Springer
New directions in medical and biomedical sciences have gradually emerged over recent
years that will change the way diseases are diagnosed and treated and are leading to the …
years that will change the way diseases are diagnosed and treated and are leading to the …
A spatial quantitative systems pharmacology platform spQSP-IO for simulations of tumor–immune interactions and effects of checkpoint inhibitor immunotherapy
C Gong, A Ruiz-Martinez, H Kimko, AS Popel - Cancers, 2021 - mdpi.com
Simple Summary Mathematical and computational models, such as quantitative systems
pharmacology (QSP) models, are becoming a popular tool in drug discovery. The …
pharmacology (QSP) models, are becoming a popular tool in drug discovery. The …
A mathematical framework for agent based models of complex biological networks
F Hinkelmann, D Murrugarra, AS Jarrah… - Bulletin of mathematical …, 2011 - Springer
Agent-based modeling and simulation is a useful method to study biological phenomena in
a wide range of fields, from molecular biology to ecology. Since there is currently no agreed …
a wide range of fields, from molecular biology to ecology. Since there is currently no agreed …