Simulating cancer behavior across multiple biological scales in space and time, ie,
multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine …

There have been many techniques developed in recent years to in silico model a variety of
cancer behaviors. Agent-based modeling is a specific discrete-based hybrid modeling …

Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …

When the immune system responds to tumour development, patterns of immune infiltrates
emerge, highlighted by the expression of immune checkpoint-related molecules such as …

Introduction: A defining hallmark of cancer is aberrant cell proliferation. Efforts to understand
the generative properties of cancer cells span all biological scales: from genetic deviations …

The aim of systems biology is to describe and understand biology at a global scale where
biological functions are recognised as a result of complex mechanisms that happen at …

The re-creation of the tumor microenvironment including tumor–stromal interactions, cell–
cell adhesion and cellular signaling is essential in cancer-related studies. Traditional two …

New directions in medical and biomedical sciences have gradually emerged over recent
years that will change the way diseases are diagnosed and treated and are leading to the …

Simple Summary Mathematical and computational models, such as quantitative systems
pharmacology (QSP) models, are becoming a popular tool in drug discovery. The …

Agent-based modeling and simulation is a useful method to study biological phenomena in
a wide range of fields, from molecular biology to ecology. Since there is currently no agreed …