The first guidance on Good Cell Culture Practice (GCCP) dates back to 2005. This document
expands this to include aspects of quality assurance for in vitro cell culture focusing on the …

Chinese hamster ovary (CHO) cells are a source of multi-ton quantities of protein
pharmaceuticals. They are, however, immortalized cells, characterized by a high degree of …

How do cells maintain relative proportions of protein complex components? Advances in
quantitative, genome-wide measurements have begun to shed light onto the roles of protein …

Adeno-associated virus (AAV) vectors are quickly becoming the vectors of choice for
therapeutic gene delivery. To date, hundreds of natural isolates and bioengineered variants …

Abstract Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial
Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine …

This article focuses on the role of the interchromatin compartment (IC) in shaping nuclear
landscapes. The IC is connected with nuclear pore complexes (NPCs) and harbors splicing …

Recent genome sequencing studies have identified several classes of complex genomic
rearrangements that appear to be derived from a single catastrophic event. These …

Cell size uniformity in healthy tissues suggests that control mechanisms might coordinate
cell growth and division. We derived a method to assay whether cellular growth rates …

Essential biological functions, such as mitosis, require tight coordination of hundreds of
proteins in space and time. Localization, the timing of interactions and changes in cellular …

In order to enhance intracellular uptake and accumulation of therapeutic nucleic acids for
improved gene therapy methods, numerous delivery vectors have been elaborated. Based …