In mammalian cells, one-third of all polypeptides are transported into or across the ER
membrane via the Sec61 channel. While the Sec61 complex facilitates translocation of all …

Advancements in volume electron microscopy mean it is now possible to generate
thousands of serial images at nanometre resolution overnight, yet the gold standard …

Interest in taking advantage of the unique spectral properties of semiconductor quantum
dots (QDs) has driven their widespread use in biological applications such as in vitro cellular …

The health humanities is a rapidly rising field, advancing an inclusive, democratizing,
activist, applied, critical, and culturally diverse approach to delivering health and well-being …

The spindle assembly checkpoint (SAC) ensures the accurate segregation of sister
chromatids during mitosis. Activation of the SAC occurs through a series of ordered …

The CRISPR/Cas9 system has revolutionized genome editing in virtually all organisms.
Although the CRISPR/Cas9 system enables the targeted cleavage of genomic DNA, its use …

In animal cells, nuclear envelope breakdown (NEBD) is required for proper chromosome
segregation. Whereas mitotic kinases have been implicated in NEBD, how they coordinate …

The enteric bacterium and intracellular human pathogen Shigella causes hundreds of
millions of cases of the diarrheal disease shigellosis per year worldwide. Shigella is …

Human immunodeficiency virus type 1 (HIV-1) encodes a transactivator of transcription (Tat)
protein, which has several functions that promote viral replication, pathogenesis, and …

The achievement of functional nanomodules for subcellular label-free measurement has
long been pursued in order to fully understand cellular functions. Here, a compact label-free …