Compared with traditional de novo drug discovery, drug repurposing has become an
attractive drug discovery strategy due to its low-cost and high efficiency. Through a …

Behavioral and psychological symptoms of dementia include agitation, depression, apathy,
repetitive questioning, psychosis, aggression, sleep problems, wandering, and a variety of …

The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published
treatment guidelines for bipolar disorder in 2005, along with international commentaries and …

These updated guidelines are based on a first edition of the World Federation of Societies of
Biological Psychiatry Guidelines for Biological Treatment of Schizophrenia published in …

Although resilience and high quality of life are demonstrated by many individuals with
congenital heart disease, a range of significant psychological challenges exists across the …

In light of the large number of studies published since the 2004 update of Schizophrenia
Patient Outcomes Research Team psychopharmacological treatment recommendations, we …

Background Users of typical antipsychotic drugs have an increased risk of serious
ventricular arrhythmias and sudden cardiac death. However, less is known regarding the …

Objective: The lifespan of people with schizophrenia is shortened compared to the general
population. We reviewed the literature on comorbid physical diseases in schizophrenia to …

ContextOf the several factors implicated in causing QT interval prolongation and torsades de
pointes, errors in the use of medications that may prolong this interval deserve special …

Background Data from 12-week placebo-controlled trials have led to mounting concerns
about increased mortality in patients with Alzheimer's disease (AD) who are prescribed …