Therapeutic significance of β-glucuronidase activity and its inhibitors: A review

P Awolade, N Cele, N Kerru, L Gummidi… - European journal of …, 2020 - Elsevier
The emergence of disease and dearth of effective pharmacological agents on most
therapeutic fronts, constitutes a major threat to global public health and man's existence …

Effect-directed analysis in food by thin-layer chromatography assays

I Cabezudo, MO Salazar, IA Ramallo, RLE Furlan - Food Chemistry, 2022 - Elsevier
Thin-layer chromatography (TLC) is widely used for food analysis and quality control. As an
open chromatographic system, TLC is compatible with microbial-, biochemical-, and …

Nutritional value and biological activity of gluten-free bread enriched with cricket powder

PŁ Kowalczewski, M Gumienna, I Rybicka, B Górna… - Molecules, 2021 - mdpi.com
Cricket powder, described in the literature as a source of nutrients, can be a valuable
ingredient to supplement deficiencies in various food products. Work continues on the …

Mulberry plant as a source of functional food with therapeutic and nutritional applications: A review

M Maqsood, R Anam Saeed, A Sahar… - Journal of food …, 2022 - Wiley Online Library
Medicinal plants from the family Moraceae have diverse applications in agriculture,
cosmetics, food, and the pharmaceutical industry. Their extensive spectrum of …

Human gut bacterial β-glucuronidase inhibition: An emerging approach to manage medication therapy

P Wang, Y Jia, R Wu, Z Chen, R Yan - Biochemical Pharmacology, 2021 - Elsevier
Bacterial β-glucuronidase enzymes (BGUSs) are at the interface of host-microbial metabolic
symbiosis, playing an important role in health and disease as well as medication outcomes …

The role of gut microbial β-glucuronidase in drug disposition and development

S Gao, R Sun, R Singh, SY So, CTY Chan… - Drug discovery today, 2022 - Elsevier
Gut microbial β-glucuronidase (gmGUS) is involved in the disposition of many endogenous
and exogenous compounds. Preclinical studies have shown that inhibiting gmGUS activity …

Mulberry Diels–Alder-type adducts: isolation, structure, bioactivity, and synthesis

SY Luo, JY Zhu, MF Zou, S Yin, GH Tang - Natural Products and …, 2022 - Springer
Abstract Mulberry Diels–Alder-type adducts (MDAAs) are unique phenolic natural products
biosynthetically derived from the intermolecular [4+ 2]-cycloaddition of dienophiles (mainly …

Beta-glucuronidase inhibition by constituents of mulberry bark

Y Bai, L Chen, YF Cao, XD Hou, SN Jia, Q Zhou… - Planta …, 2021 - thieme-connect.com
Intestinal bacterial β-glucuronidases, the key enzymes responsible for the hydrolysis of
various glucuronides into free aglycone, have been recognized as key targets for treating …

Inhibition and structure-activity relationship of dietary flavones against three Loop 1-type human gut microbial β-glucuronidases

P Wang, R Wu, Y Jia, P Tang, B Wei, Q Zhang… - International Journal of …, 2022 - Elsevier
Gut microbial β-glucuronidases (GUSs) inhibition is a new approach for managing some
diseases and medication therapy. However, the structural and functional complexity of GUSs …

2, 5-Disubstituted furan derivatives containing 1, 3, 4-thiadiazole moiety as potent α-glucosidase and E. coli β-glucuronidase inhibitors

YS Li, M He, TS Zhou, Q Wang, L He, SJ Wang… - European Journal of …, 2021 - Elsevier
Abstract In this paper, the 2, 5-disubstituted furan derivatives containing 1, 3, 4-thiadiazole
were synthesized and screened for their inhibitory activity against α-glucosidase and β …