Drug-loaded chitosan scaffolds for periodontal tissue regeneration

GAN Atia, HK Shalaby, M Zehravi, MM Ghobashy… - Polymers, 2022 - mdpi.com
Chitosan is a natural anionic polysaccharide with a changeable architecture and an
abundance of functional groups; in addition, it can be converted into various shapes and …

Review on additives in hydrogels for 3D bioprinting of regenerative medicine: from mechanism to methodology

W Fang, M Yang, M Liu, Y Jin, Y Wang, R Yang… - Pharmaceutics, 2023 - mdpi.com
The regeneration of biological tissues in medicine is challenging, and 3D bioprinting offers
an innovative way to create functional multicellular tissues. One common way in bioprinting …

Understanding intracellular trafficking and anti-inflammatory effects of minocycline chitosan-nanoparticles in human gingival fibroblasts for periodontal disease …

V Martin, IAC Ribeiro, MM Alves, L Gonçalves… - International journal of …, 2019 - Elsevier
Periodontal diseases remain a challenge due to a complex interplay of factors involving a
chronic inflammatory activation and bacteria internalization in periodontal cells. In this work …

Levofloxacin-loaded bone cement delivery system: Highly effective against intracellular bacteria and Staphylococcus aureus biofilms

M Ferreira, O Rzhepishevska, L Grenho… - International journal of …, 2017 - Elsevier
Staphylococcus aureus is a major pathogen in bone associated infections due to its ability to
adhere and form biofilms on bone and/or implants. Moreover, recrudescent and chronic …

Unveiling the Osteogenic Potential of Tetracyclines: A Comparative Study in Human Mesenchymal Stem Cells

V Martin, AF Bettencourt, C Santos, MH Fernandes… - Cells, 2023 - mdpi.com
Tetracyclines (TCs) are a class of broad-spectrum antibiotics with diverse
pharmacotherapeutic properties due to their various functional groups being attached to a …

Impact of local drug delivery and natural agents as new target strategies against periodontitis: new challenges for personalized therapeutic approach

G Viglianisi, S Santonocito, SM Lupi… - … in Chronic Disease, 2023 - journals.sagepub.com
Periodontitis is a persistent inflammation of the soft tissue around the teeth that affects 60%
of the population in the globe. The self-maintenance of the inflammatory process can cause …

Expansible thermal gelling foam aerosol for vaginal drug delivery

L Mei, J Chen, S Yu, Y Huang, Y Xie, H Wang… - Drug Delivery, 2017 - Taylor & Francis
Vaginal delivery of antimicrobial drugs is the most effective method for the local treatment of
the vaginal infections. However, current vaginal drug delivery systems (VDDS), including …

Release characteristics of enoxaparin sodium-loaded polymethylmethacrylate bone cement

H Sun, X Ma, Z Li, J Liu, W Wang, X Qi - Journal of Orthopaedic Surgery …, 2021 - Springer
Background This study aimed to prepare the polymethylmethacrylate (PMMA) bone cement
release system with different concentrations of enoxaparin sodium (ES) and to investigate …

Doxycycline restores the impaired osteogenic commitment of diabetic-derived bone marrow mesenchymal stromal cells by increasing the canonical WNT signaling

PS Gomes, M Resende, MH Fernandes - Molecular and Cellular …, 2020 - Elsevier
Diabetes mellitus comprehends a group of chronic metabolic disorders, associated with
damage and dysfunction of distinct tissues, including bone. At the cellular level, an impaired …

Design, fabrication and structural optimization of tubular carbon/Kevlar®/PMMA/graphene nanoplate composite for bone fixation prosthesis

F Nasiri, S Ajeli, D Semnani, M Jahanshahi… - Biomedical …, 2018 - iopscience.iop.org
The present work investigates the mechanical properties of tubular carbon/Kevlar®
composite coated with poly (methyl methacrylate)/graphene nanoplates as used in the …