MUC1 and MUC16: critical for immune modulation in cancer therapeutics

X Chen, IK Sandrine, M Yang, J Tu, X Yuan - Frontiers in immunology, 2024 - frontiersin.org
The Mucin (MUC) family, a range of highly glycosylated macromolecules, is ubiquitously
expressed in mammalian epithelial cells. Such molecules are pivotal in establishing …

[HTML][HTML] Insights into therapeutic peptides in the cancer-immunity cycle: Update and challenges

X Zhang, Y Wu, J Lin, S Lu, X Lu, A Cheng… - … Pharmaceutica Sinica B, 2024 - Elsevier
Immunotherapies hold immense potential for achieving durable potency and long-term
survival opportunities in cancer therapy. As vital biological mediators, peptides with high …

Altered MUC1 epitope-specific CTLs: A potential target for immunotherapy of pancreatic cancer

J Hong, G Guo, S Wu, S Lin, Z Zhou… - Journal of Leukocyte …, 2022 - academic.oup.com
The efficacy of conventional treatments for pancreatic cancer remains unsatisfactory, and
immunotherapy is an emerging option for adjuvant treatment of this highly deadly disorder …

Altered HLA‐A2‐restricted TP53 epitope induces specific CTL cytotoxicity against hepatocellular carcinoma

C Ye, S Lin, J Hong, F Liu, G Guo… - European Journal of …, 2023 - Wiley Online Library
High‐frequency mutation of the TP53 tumor suppressor gene is observed in multiple human
cancers, which promotes cancer progression. However, the mutated gene‐encoded protein …

[HTML][HTML] Recent progress on MHC-I epitope prediction in tumor immunotherapy

X Wang, Z Yu, W Liu, H Tang, D Yi… - American journal of …, 2021 - ncbi.nlm.nih.gov
Tumor immunotherapy has now become one of the most potential therapy for those
intractable cancer diseases. The antigens on the cancer cell surfaces are the keys for the …

TRAF6-overexpressing dendritic cells loaded with MUC1 peptide enhance anti-tumor activity in B16-MUC1 melanoma-bearing mice

J Wang, Y Liu, W Ni, X Wu, J Zhou, Z Zhang… - International …, 2022 - Elsevier
Tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) signaling is a critical
positive mechanism for the development, homeostasis and activation of immune cells. We …

MiRNA-485-5p inhibited the proliferation and promoted the apoptosis of hepatocellular carcinoma cells by targeting MUC1

M Li, D Zhu, X Peng, P Liu, F Yang, H Luo, X Zhang… - 2020 - researchsquare.com
Background The downregulation of miRNA-485-5-p was related to prognosis of various
cancers, including hepatocellular carcinoma (HCC), while MUC1 was aberrantly expressed …