Nonhuman primate (NHP) models of Parkinson's disease (PD) play an essential role in the
understanding of PD pathophysiology and the assessment of PD therapies. NHP research …

Despite the importance and frequency of levodopa-induced dyskinesias, little is known
about their causal mechanisms. In this study, electrophysiological single-unit recordings of …

Non-human primate (NHP) models of Parkinson's disease (PD) have been essential in
understanding the pathophysiology and neural mechanisms underlying PD. The most …

Minocycline has been shown to exert anti‐inflammatory effects underlying its putative
neuroprotective properties in the 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP) …

Whether direct manipulation of Parkinson's disease (PD) risk genes in the adult monkey
brain can elicit a Parkinsonian phenotype remains an unsolved issue. Here, we used an …

Previous physiological studies have revealed changes in firing rates and synchronization of
pallidal neurons in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) primate …

To replicate the sleep–wake disorders of Parkinson's disease (PD) and to understand the
temporal relationship between these sleep disturbances and the occurrence of …

Cyclones are significant drivers of change within mangrove ecosystems with the extent of
initial damage determined by storm severity, location and distribution (exposure), and …

Clinical studies to date have failed to establish therapeutic benefit of glial cell-derived
neurotrophic factor (GDNF) in Parkinson's disease (PD). In contrast to previous nonclinical …

Parkinsonian patients often experience sleep/wake disturbances, which may appear at an
early stage of the disease; however, these disturbances have not been fully described. To …