Summary tRNAs are subject to numerous modifications, including methylation. Mutations in
the human N 7-methylguanosine (m 7 G) methyltransferase complex METTL1/WDR4 cause …

The discovery of the genetic code and tRNAs as decoders of the code transformed life
science. However, after establishing the role of tRNAs in protein synthesis, the field moved …

Pseudouridylation (Ψ) is the most abundant and widespread type of RNA epigenetic
modification in living organisms; however, the biological role of Ψ remains poorly …

Transfer RNA (tRNA) is present at tens of millions of transcripts in a human cell and is the
most abundant RNA in moles among all cellular RNAs. tRNA is also the most extensively …

Once deemed heretical, emerging evidence now supports the notion that the inheritance of
acquired characteristics can occur through ancestral exposures or experiences and that …

More than 100 distinct chemical modifications to RNA have been characterized so far.
However, the prevalence, mechanisms and functions of various RNA modifications remain …

Distinguishing the few disease-related variants from a massive number of passenger
variants is a major challenge. Variants affecting RNA modifications that play critical roles in …

Transfer RNA is heavily modified and plays a central role in protein synthesis and cellular
functions. Here we demonstrate that ALKBH3 is a 1-methyladenosine (m1A) and 3 …

Abstract Treatment selections are very limited for patients with advanced nasopharyngeal
carcinoma (NPC) experiencing disease progression. Uncovering mechanisms underlying …

Specific, regulated modification of RNAs is important for proper gene expression,. tRNAs are
rich with various chemical modifications that affect their stability and function,. 7 …