Posttranscriptional processing of RNA molecules is a common strategy to enlarge the
structural and functional repertoire of RNomes observed in all 3 domains of life …

Measuring multiple omics profiles from the same single cell opens up the opportunity to
decode molecular regulation that underlies intercellular heterogeneity in development and …

Neurodegenerative diseases (NDs) are becoming increasingly prevalent in the world, with
an aging population. In the last few decades, due to the devastating nature of these …

Tumourigenesis and cancer progression require enhanced global protein translation,–.
Such enhanced translation is caused by oncogenic and tumour-suppressive events that …

Limitation for amino acids is thought to regulate translation in mammalian cells primarily by
signaling through the kinases mTORC1 and GCN2. We find that a selective loss of arginine …

Although more than 100 different types of RNA modifications have been characterized
across all living organisms, surprisingly little is known about the modified positions and their …

Orellana et al.(2021) and Dai et al.(2021) demonstrate that increased m 7 G modification of
a subset of tRNAs by the METTL1/WDR4 complex stabilizes these mRNAs against decay …

Interest in circulating RNAs for monitoring and diagnosing human health has grown
significantly. There are few datasets describing baseline expression levels for total cell-free …

Increasing evidence implicates the critical roles of various epitranscriptomic RNA
modifications in different biological processes. Methyltransferase METTL8 installs 3 …

The discovery of mechanisms that alter genetic information via RNA editing or introducing
covalent RNA modifications points towards a complexity in gene expression that challenges …