A tRNA-derived fragment competes with mRNA for ribosome binding and regulates translation during stress
J Gebetsberger, L Wyss, AM Mleczko, J Reuther… - RNA biology, 2017 - Taylor & Francis
Posttranscriptional processing of RNA molecules is a common strategy to enlarge the
structural and functional repertoire of RNomes observed in all 3 domains of life …
structural and functional repertoire of RNomes observed in all 3 domains of life …
[HTML][HTML] Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation
N Wang, J Zheng, Z Chen, Y Liu, B Dura… - Nature …, 2019 - nature.com
Measuring multiple omics profiles from the same single cell opens up the opportunity to
decode molecular regulation that underlies intercellular heterogeneity in development and …
decode molecular regulation that underlies intercellular heterogeneity in development and …
[HTML][HTML] Small non-coding RNAs: new class of biomarkers and potential therapeutic targets in neurodegenerative disease
CN Watson, A Belli, V Di Pietro - Frontiers in genetics, 2019 - frontiersin.org
Neurodegenerative diseases (NDs) are becoming increasingly prevalent in the world, with
an aging population. In the last few decades, due to the devastating nature of these …
an aging population. In the last few decades, due to the devastating nature of these …
Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics
Tumourigenesis and cancer progression require enhanced global protein translation,–.
Such enhanced translation is caused by oncogenic and tumour-suppressive events that …
Such enhanced translation is caused by oncogenic and tumour-suppressive events that …
[HTML][HTML] Translational control through differential ribosome pausing during amino acid limitation in mammalian cells
AM Darnell, AR Subramaniam, EK O'Shea - Molecular cell, 2018 - cell.com
Limitation for amino acids is thought to regulate translation in mammalian cells primarily by
signaling through the kinases mTORC1 and GCN2. We find that a selective loss of arginine …
signaling through the kinases mTORC1 and GCN2. We find that a selective loss of arginine …
RMBase: a resource for decoding the landscape of RNA modifications from high-throughput sequencing data
Although more than 100 different types of RNA modifications have been characterized
across all living organisms, surprisingly little is known about the modified positions and their …
across all living organisms, surprisingly little is known about the modified positions and their …
[HTML][HTML] m7G tRNA modification reveals new secrets in the translational regulation of cancer development
O Katsara, RJ Schneider - Molecular cell, 2021 - cell.com
Orellana et al.(2021) and Dai et al.(2021) demonstrate that increased m 7 G modification of
a subset of tRNAs by the METTL1/WDR4 complex stabilizes these mRNAs against decay …
a subset of tRNAs by the METTL1/WDR4 complex stabilizes these mRNAs against decay …
[HTML][HTML] Total extracellular small RNA profiles from plasma, saliva, and urine of healthy subjects
Interest in circulating RNAs for monitoring and diagnosing human health has grown
significantly. There are few datasets describing baseline expression levels for total cell-free …
significantly. There are few datasets describing baseline expression levels for total cell-free …
[HTML][HTML] Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification
Increasing evidence implicates the critical roles of various epitranscriptomic RNA
modifications in different biological processes. Methyltransferase METTL8 installs 3 …
modifications in different biological processes. Methyltransferase METTL8 installs 3 …
Understanding RNA modifications: the promises and technological bottlenecks of the 'epitranscriptome'
The discovery of mechanisms that alter genetic information via RNA editing or introducing
covalent RNA modifications points towards a complexity in gene expression that challenges …
covalent RNA modifications points towards a complexity in gene expression that challenges …