Mutations in the tRNA methyltransferase 1 (TRMT1) gene have been identified as the cause
of certain forms of autosomal-recessive intellectual disability (ID). However, the molecular …

Nonsense mutations change an amino acid codon to a premature termination codon (PTC)
generally through a single‐nucleotide substitution. The generation of a PTC results in a …

Three stop codons (UAA, UAG and UGA) terminate protein synthesis and are almost
exclusively recognized by release factors. Here, we design de novo transfer RNAs (tRNAs) …

Colorectal cancer (CRC) is the third most common malignance. Although great efforts have
been made to understand the pathogenesis of CRC, the underlying mechanisms are still …

The broad application of next-generation sequencing technologies in conjunction with
improved bioinformatics has helped to illuminate the complexity of the transcriptome, both in …

Small RNAs participate in several cellular processes, including splicing, RNA modification,
mRNA degradation, and translational arrest. Traditional methods for sequencing small …

Translation of protein from mRNA is a complex multi-step process that occurs at a non-
uniform rate. Variability in ribosome speed along an mRNA enables refinement of the …

Transfer RNAs (tRNAs), traditionally considered to participate in protein translation, were
interspersed in the entire genome. Recent studies suggested that dysregulation was …

Fragmentation of tRNAs generates a family of small RNAs collectively known as tRNA-
derived fragments. These fragments vary in sequence and size but have been shown to …

Viruses are traditionally thought to be under selective pressure to maintain compact
genomes and thus depend on host cell translational machinery for reproduction. However …