The interferon (IFN) system is one of the first lines of defense activated against invading viral
pathogens. Upon secretion, IFNs activate a signaling cascade resulting in the production of …

Type I interferons (IFNs) are critical effector cytokines of the immune system and were
originally known for their important role in protecting against viral infections; however, they …

Type I interferons (IFN-I) exert pleiotropic biological effects during viral infections, balancing
virus control versus immune-mediated pathologies, and have been successfully employed …

Objectives Dissecting the underlying mechanism of T cells remodeling mediated by
interferon α (IFN-α) is indispensable for achieving an optimum therapeutic response in …

Infectious mononucleosis, caused by infection with the human gamma-herpesvirus Epstein-
Barr virus (EBV), manifests with one of the strongest CD8+ T-cell responses described in …

Type I interferons (IFN), immediately triggered following most viral infections, play a pivotal
role in direct antiviral immunity and act as a bridge between innate and adaptive immune …

Influenza is an acute respiratory infection causing high morbidity and mortality in annual
outbreaks worldwide. Antiviral drugs are limited and pose the risk of resistance …

Clinical administration of Interferon α (IFNα) resulted in limited therapeutic success against
some viral infections. Immune modulation of CD8+ T cell responses during IFNα therapy is …

Type I interferons (IFN), which are immediately induced after most virus infections, are
central for direct antiviral immunity and link innate and adaptive immune responses …

Chronic hepatitis B virus (HBV) infection continues to be a major health problem worldwide
and remains hard to be cured. Therapy with interferon (IFN) α is an important method for the …